罗布麻提取物对STZ糖尿病大鼠肾损害的防护作用  

Protective effect of extract of Apocynum venetum on kidneys of streptozotocin-induced diabetic rats

作　　者：陈红艳[1] 王建华[1] 耿淼[1] 吴向起[1] 严莉[1] 黄凯[1] 邵丽勉[1] 杨新波[1] 黄正明[2] 

机构地区：[1]解放军总医院老年医学研究所,北京100853 [2]解放军302医院药学部,北京100039

出　　处：《药学学报》2010年第1期26-30,共5页Acta Pharmaceutica Sinica

基　　金："十一五"军队中医药专项基金资助项目(2006213002)

摘　　要：本文探讨了罗布麻提取物(AV)对STZ大鼠糖尿病肾脏损害的防护作用及部分作用机制。采用链脲佐菌素(STZ)诱导大鼠糖尿病模型方法,观察8周时大鼠血糖、肾功能、氧化应激等指标以及经AV治疗后的变化。结果显示,糖尿病大鼠的血糖、血尿素氮、24h尿蛋白含量、尿量、肾脏肥大指数、肾皮质MDA含量显著升高;肾皮质SOD、GSH活性显著降低。AV干预治疗组的上述指标得到改善,具有显著性差异。实验结果表明,AV对STZ大鼠糖尿病肾功能有明显的防护作用,其作用可能与抑制肾脏氧化应激作用有关。The aim of this study is to investigate the effects and mechanism of extract of Apocynum venetum （AV） on kidneys of streptozotocin-induced diabetic rats. Diabetes mellitus （DM） was induced in rats by intraperitoneal injection of streptozotocin （STZ）. The indexes of the blood glucose, renal function and oxidative stress were observed. The DM rats were administrated with the AV for 8 weeks, the above-mentioned indexes were detected. The blood glucose level, BUN, 24 h urine protein excretion, urine volume, renal index, renal cortex’s MDA level in model groups all increased significantly. Renal cortex’s SOD and GSH activities decreased significantly compared with the normal control group （P 0.05）. The above-mentioned indexes were significantly improved by the AV treatment （P 0.05）. AV have protective effects on renal function of kidneys of streptozotocin-induced diabetic rats, and maybe via inhibition of the renal oxidative stress.

关 键 词：罗布麻提取物 糖尿病 血糖 肾功能 氧化应激 

分 类 号：R285[医药卫生—中药学]