论肝窦内皮窗孔异常是肝脾失调致动脉粥样硬化的微观病机  

Discussion on dysfunction of fenestrae as the micro-pathogenesis for atherosclerosis caused by uncoordinated liver and spleen

作　　者：孙学刚[1] 符秀琼[1] 冯沃成[1] 黎春华[1] 吕志平[1] 

机构地区：[1]南方医科大学中医药学院分子生物学实验室,广东广州510515

出　　处：《山东中医药大学学报》2010年第1期11-13,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:30973699)

摘　　要：脾主健运与肝主疏泄在生理上相辅相成,协同运化精微,与现代解剖学的肝脏(在胁之肝)功能密切相关。肝脏脂质代谢紊乱是肝脾不调致动脉粥样硬化(AS)的重要原因,与肝窦内皮窗孔的结构和功能异常相关。因此提出假说:解剖学的肝脏可能是肝脾不调致AS的靶器官,肝窦内皮窗孔形成的肝筛功能异常是脂质代谢紊乱的重要因素,肝窦内皮窗孔异常可能是肝脾不调致AS的超微结构之一。There are close relationship between spleen having the function to transport and transform nutrients and liver governing smooth flow of qi. Liver and spleen synergistically transform and disperse essence in physiology. The functions of spleen and liver in, traditional Chinese medieine（TCM） have intact relationship with liver that locate under the ribs in anatomy. The disorder of lipid metabolism of liver is important cause for atheroselerosis（AS） whose pathogenesis is uncoordinated liver and slpecn in TCM. The disorder is related to abnormal structure and function of liver sieve that composed of sinusoidal endothelial cell fenestrae. We proposed our hypothesis that anatomical liver is a possible target organ of AS. Dysfunction of liver composed of fenestrae is the pathogenesis for AS that caused by uncoordinated liver and spleen in TCM.

关 键 词：肝脾不调 动脉粥样硬化 肝窦内皮细胞 窗孔 肝筛 

分 类 号：R259.435[医药卫生—中西医结合]