果糖注射液对冠心病合并糖尿病患者血糖及胰岛素水平和血压的影响  

Effects of Fructose Injection on Coronary Heart Disease Combined with T2DM

作　　者：王祥[1] 户富栋[1] 谢志江[1] 钟禹成[1] 何传飞[1] 

机构地区：[1]华中科技大学附属协和医院心内科,湖北省武汉市430022

出　　处：《中国全科医学》2010年第2期137-141,共5页Chinese General Practice

摘　　要：目的探讨果糖注射液对冠心病合并糖尿病患者血糖、胰岛素水平和血压的影响,并观察果糖注射液的疗效。方法将60例冠心病合并2型糖尿病(T2DM)患者随机分为果糖注射液组(试验组)和0.9%氯化钠注射液组(对照组),各30例,分别给予500ml5%果糖注射液和0.9%氯化钠注射液,3h输完,1次/d,共3d。静脉滴注第0h、1h、2h、3h测静脉血糖、胰岛素水平,连测3d;给药前和停药后1d定时测空腹静脉血糖、胰岛素水平和血压,并记录心绞痛发作次数等。结果静脉滴注过程中,试验组血糖和胰岛素水平呈轻缓上升趋势,2h左右达峰值,平均升高值分别为0.03mmol/L和0.50mU/L,随后均缓和下降;而对照组静脉滴注开始时血糖和胰岛素水平就缓慢持续下降,并在静脉滴注结束时达谷值,血糖与胰岛素平均下降值分别为0.06mmol/L和0.22mU/L。试验组和对照组干预前后血糖及胰岛素变化间差异无统计学意义(P>0.05);干预前后两组患者空腹血糖、胰岛素和舒张压间差异无统计学意义(P>0.05),但对照组收缩压较干预前升高(4.2±10.0)mmHg,差异有统计学意义(P<0.05)。干预后试验组显效5例,改善16例,无效9例,对照组分别为3、9、18例,两组疗效间差异有统计学意义(P<0.05)。结论5%果糖注射液不引起冠心病合并2型糖尿病患者血糖、胰岛素水平和血压的明显波动,并对心绞痛有一定的疗效。Objective To investigate the effects of fructose injection on levels of blood glucose （ BG）, insulin and blood pressure （BP） in patients with coronary heart disease （CHD） combined with type 2 diabetes （T2DM）. Methods Sixty CHD patients with rr2DM were divided into groups test （ injected with fructose injection） and control （ with 0. 9% sodium chloride injection）, 30 in each~ The injections were finished within 3 h, once/d, 3 d. The levels of venous BG and insulin were detec- ted at hours 0, 1, 2, 3, for 3 d. Levels of fasting venous BG, insulin and BP were periodically measured before injection or 1 d after drug withdrawal, and angina attack frequencies recorded. Results In the process of infusion in test group, the levels of BG and insulin rose lightly and slowly, getting to peak at hours 2 or so, with the average increase values of O. 03 mmol/L, 0. 50 mU/L, respectively, and then decreased slowly, while in control group, levels of BG and insulin declined slowly and continu- ously, reaching valley value at the end of infusion, with the average values of O. 06 mmol/L and O. 22 mU/L, respectively, the difference in BG and insulin change, fasting BG, insulin level and DBP was not significant before and after intervention （P 〉 0 . 05） But SBP rose （4. 2± 10. 0 mm Hg） as compared with pre - intervention in control group, the difference was significant （P〈0. 05） After intervention, marked effect was noted in 5 patients, improvement in 16, no effect in 9 in test group, while in control, 3, 9, 18, respectively, the difference was significant （P 〈 0. 05 ）. Conclusion The 5% fructose injection, not causing conspicuous fluctuation of BG, insulin and BP in CHD patients combined with T2DM, is of some effect on angina pectoris.

关 键 词：冠心病 糖尿病 2型 果糖 血糖 胰岛素 血压 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]