流行性乙型脑炎减毒活疫苗血清学效果观察  

Observation on Immune Effect of the Live Attenuated Japanese Encephalitis Virus Vaccine

作　　者：黄佐林[1] 吴季南[1] 李新国[1] 

机构地区：[1]卫生部武汉生物制品研究所

出　　处：《中国计划免疫》1998年第5期286-288,共3页Chinese Journal of Vaccines and Immunization

摘　　要：为进一步考核用ＳＡ１４－１４－２株生产的流行性乙型脑炎（乙脑）减毒活疫苗接种儿童后的血清学效果，在湖北省乙脑流行区，对某山区小学从未接种过乙脑疫苗的９７名７～１３岁健康小学生接种该疫苗。免疫前和免疫后１个月采血检测乙脑中和抗体，结果：免前中和抗体阳性者８６人（８８．６６％），中和指数ＧＭＴ为１：６９５．３２，免疫１针后１个月，抗体阳性率达到１００％，中和指数ＧＭＴ为１：２７７８．２７；免疫前抗体阴性的１１名儿童，免疫后１个月全部阳转；免疫前中和指数≥１１０００者５４人（占５５．６７％），免疫后１个月增至８１人（８３．５１％）；６０．８２％的儿童免疫后１个月中和抗体滴度较免疫前增长≥２倍。We examined the immune effect of the live attenuated Japanese encephalitis vaccine strain SA14-14-2 in an epidemic area in Hubei Province in a primary school of mountain area by serologic testing. 97 healthy pupils of 7-13 years old who had not been vaccinated by Japanese encephalitis virus(JEV) vaccine before were chosen. The neutralizing antibody against the vaccine virus before and 1 month after 1 dose immunization of the vaccine was tested. The results showed that before immunization, the JEV neutralizing antibody positive rate was 88.66%(86/97), the GMT was 1: 695.32, but they reached to 100% and 1: 2778.27 respectively after vaccination. 11 pupils who were seronegative all became positively seroconverted after vaccination, the percentage of pupil with ≥ 11 000 raised from 55.67%(54/97) to 83.51%(81/97) after vaccination, and so was the neutralizing antibody titer from 1 fold to ≥2 folds in 60.82% of the vaccinated pupils. It demonstrats a satisfactory immune effect of SA14-14-2 JEV vaccine strain.

关 键 词：乙型脑炎 减毒活疫苗 中和抗体 血清学 

分 类 号：R512.320.1[医药卫生—内科学]