电针“曲池”“足三里”“神门”对自发性高血压大鼠血压及血管紧张素Ⅱ、醛固酮及心钠素的影响  

Effect of Electroacupuncture of Different Acupoints on Blood Pressure,Plasma AngiotensinⅡ,Aldosterone and Atrial Natriuretic Peptide in Spontaneous Hypertension Rats

作　　者：刘婉宁[1] 金侣位[1] 韩东伟[1] 任晓暄[1] 朱江[1] 张露芬[1] 

机构地区：[1]北京中医药大学针灸学院,北京100029

出　　处：《针刺研究》2009年第6期393-397,共5页Acupuncture Research

基　　金：国家"973"计划(No.2006CB504503;No.2005CB523308)

摘　　要：目的:通过观察电针不同穴位对自发性高血压大鼠(SHR)血压及血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)及心钠素(ANP)的影响,探讨不同穴位对SHR血压影响的规律及可能机制。方法:雄性SHR60只随机分为模型组、曲池组、足三里组、神门组、肩髃组及尾尖组,每组10只。10只同体重Wistar大鼠作为正常组。分别电针"曲池""足三里""神门""肩髃"及尾尖,连续波,频率2Hz,强度2mA,电针30min。使用无创血压测量系统检测针刺前后各组大鼠收缩压和舒张压,放射免疫法检测血浆AngⅡ、ALD及ANP含量。结果:曲池组、足三里组、神门组收缩压及舒张压较针刺前及模型组均明显降低(P<0.05);肩髃组、尾尖组收缩压及舒张压与针刺前及模型组比较,差异均无统计学意义(P>0.05);曲池组和神门组治疗后收缩压低于肩髃组和尾尖组(P<0.05);曲池组、足三里组及神门组舒张压较肩髃组及尾尖组显著降低(P<0.05)。模型组血浆AngⅡ显著低于正常组,血浆ALD水平显著高于正常组(P<0.05);曲池组、足三里组、神门组血浆AngⅡ及足三里组、神门组ALD水平与模型组比较显著下降(P<0.05);神门组血浆AngⅡ及ALD水平低于尾尖组(P<0.05)。模型组血浆ANP水平显著低于正常组(P<0.05);治疗后神门组血浆ANP水平显著高于模型组和肩髃组(P<0.05)。结论:电针"曲池""神门""足三里"可以即刻降低SHR血压,其降压作用可能与对血浆AngⅡ、ALD及ANP的调整作用有关,并有一定的穴位特异性作用。Objective To observe the effect of electroacupuncture （EA） of different acupoints on blood pressure （BP）, plasma angiotensin （Ang） Ⅱ , aldosterone （ALP） and atrial natriuretic peptide （ANP） of SHR, so as to observe the relative specificity of effects of acupoints. Methods A total of 60 SHR were randomly divided into model, Quchi （LI 11）, Zusanli（ST 36）, Shenmen （HT 7）, Jianyu （LI 15） and non-acupoint groups, with 10 cases in each. Other 10 Wistar rats were composed of normal group. EA （2 Hz, 2 mA） was applied to LI 11, ST 36, HT 7, LI 15 and non-acupoint for 30 min, followed by measuring BP with BP-6 system. Plasma Ang Ⅱ ,ALD and ANP contents were assayed by radioimmunoassay. Results Compared with control group and pre-treatment, both systolic pressure （SP） and diastolic pressure （DP） of Quchi （LI 11）, Zusanli （ST 36） and Shenmen （HT 7） groups lowered significantly （P〈0.05）. No significant differences were found in the SP and DP of Jianyu （LI 15） and non-acupoint groups （P〉0.05）. After EA, the SP of Quchi （LI 11） and Shenmen （HT 7） groups were significantly lower than that of Jianyu （LI 15） and non-acupoint groups （P〈0.05） ; and the DP of Quchi （LI 11 ）, Zusanli （ST 36） and Shenmen （HT 7） groups were markedly lower than that of Jianyu （LI 15） and non-acupoint groups （P〈0.05）. Compared with normal group, the contents of plasma Ang Ⅱ and ANP of model group decreased siclnificantly, and plasma ALD level of model aroup increased remarkably （P〈0.05）. Compared with model group, plasma AngⅡ levels in Quchi （LI 11）, Zusanli （ST 36） and Shenmen （HT 7） groups and ALD in Zusanli （ST 36） and Shenmen （HT 7） groups lowered significantly （P,0.05）, and plasma ANP content in Shenmen （HT 7） group increased obviously （P〈0.05）. Conclusion EA of LI 11, HT 7 and ST 36 can effectively lowered both DP and SP in SHR, which may be closely related to its effects in regulating th

关 键 词：自发性高血压 电针 血管紧张素 醛固酮 心钠素 

分 类 号：R246.1[医药卫生—针灸推拿学]