Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components  

作　　者：Han-Lin Gong Wen-Fu Tang Qin Yu Jin Xiang Qing xia Guang-Yuan Chen Xi Huang Mao-Zhi Liang 

机构地区：[1]Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China [2]Department of Clinical Pharmacology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China

出　　处：《World Journal of Gastroenterology》2009年第47期5992-5999,共8页世界胃肠病学杂志（英文版）

基　　金：Supported by The National Natural Science Foundation of China,No.30400576 and No.30672588

摘　　要：AIM:To investigate the effect of severe acute pan- creatitis(SAP)on pharmacokinetics of Da-Cheng-Qi Decoction(DCQD)components in rats. METHODS:Rats were divided into SAP group and sham-operation group as a control group(n=6). Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS:Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage.The Cmax(chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023) and AUC(rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272)of DCQD component were obviously lower in SAP group than in control group.The T1/2α of chrysophanol and rheochrysidin(P=0.0467 and 0.0005,respectively)and Tmax of chrysophanol and rheochrysidin(P=0.0101 and 0.0037,respectively) lasted longer in SAP group than in control group. CONCLUSION:SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters.AIM：To investigate the effect of severe acute pan- creatitis（SAP）on pharmacokinetics of Da-Cheng-Qi Decoction（DCQD）components in rats. METHODS：Rats were divided into SAP group and sham-operation group as a control group（n=6）. Rhein,chrysophanol,rheochrysidin,magnolol,hesperidin and naringin in DCQD were quantified in rat serum by high performance liquid chromatography tandem mass spectrometry for studying their pharmacokinetics. RESULTS：Early absorption of each DCQD component was tended to degrade in SAP group after treatment with DCQD by gavage.The Cmax（chrysophanol,P= 0.0059;rheochrysidin,P=0.0288;magnolol,P= 0.0487;hesperidin,P=0.0277;naringin,P=0.0023） and AUC（rhein,P=0.0186;chrysophanol,P=0.0013; magnolol,P=0.001;hesperidin,P=0.0081;naringin, P=0.0272）of DCQD component were obviously lower in SAP group than in control group.The T1/2α of chrysophanol and rheochrysidin（P=0.0467 and 0.0005,respectively）and Tmax of chrysophanol and rheochrysidin（P=0.0101 and 0.0037,respectively） lasted longer in SAP group than in control group. CONCLUSION：SAP can significantly impact the ab-sorption of DCQD components in rats and their phar-macokinetic parameters.

关 键 词：Severe acute pancreatitis Da-Cheng-Qi Decoction  Pharmacokinetics Components 

分 类 号：S859.796[农业科学—临床兽医学] S858.292[农业科学—兽医学]