邻位和间位取代苯胺与丙烯腈的单氰乙基化反应  

Mono-cyanoethylation of Acrylonitrile with o-Substituted and m-Substituted Anilines

作　　者：赵莹[1] 赵芳[1] 谭晓燕[1] 李姣娟[1] 

机构地区：[1]中南林业科技大学应用化学研究所,株洲412006

出　　处：《化学通报》2010年第1期83-87,共5页Chemistry

基　　金：湖南省科技厅科研基金项目(2007FJ4156)资助

摘　　要：对于邻位、间位取代苯胺与丙烯腈发生单氰乙基反应生成相应的N-氰乙基邻位取代苯胺和N-氰乙基间位取代苯胺的过程,AlCl3具有高的催化活性。在芳香胺/丙烯腈/AlCl3=1/1.10/(0.05～0.10)(摩尔比)、反应温度60～80℃,反应时间6～10h的条件下,反应的收率达87%～90%。用毛细管气相色谱法分析了单氰乙基化反应中各组份的含量;所合成的7种N-氰乙基邻位取代苯胺和N-氰乙基间位取代苯胺用DTA-TG、UV、IR、1HNMR和EA进行了物性和结构表征。Mono-cyanoethylation addition reactions of o-substituted or m-substituted anilines with aerylonitrile have been carried out in the presence of AlCl3 , resulting in N-β-cyanoethyl-o-substituted anilines, N-β-cyanoethyl-m- substituted anilines in high yield. Under the conditions of mole ratio of the reactants as substituted anilines： acrylonitrile：AlCl3= 1： 1.10：（0.05 - 0. 10） , the temperature of 60 -80 ℃ for 6 - 10 h, the yields of mono- cyanoethyl substituted anilines were 87% - 90 % ,and capillary gas chromatographic determination method was used for the contents analysis of N-β-cyanoethyl-o-substituted anilines or N-β-cyanoethyl-p-substituted anilines among mono-cyanoethylation reactions. All of products were characterized by DTA-TG, UV-Vis, FTIR, ^1H NMR, and elemental analyses.

关 键 词：ALCL3 氰乙基化反应 取代苯胺 气相色谱分析 

分 类 号：O621.25[理学—有机化学]