针刺对快速老化小白鼠(SAM-P/10)脑组织凋亡阳性细胞数的影响  

Effects of Acupuncture on Cell Apoptosis in the Brain of SAM-P/10

作　　者：韩景献[1] 杨增瑞[1] 郑灏泳[1] 刘庆忠[1] 石学敏[1] 

机构地区：[1]天津中医学院第一附属医院,300193

出　　处：《针刺研究》1998年第4期266-268,共3页Acupuncture Research

摘　　要：为探索脑萎缩与细胞凋亡的关系及针刺治疗脑萎缩的作用机制，本研究用DNA末端标记的方法检测脑萎缩小白鼠SAM－P／10及其同源正常老化小白鼠SAM－R／1脑组织细胞凋亡的情况。结果表明，在8月龄的SAM－R／1及SAM－P／10小鼠各脑区均存在细胞凋亡现象，其中SAM－P／10小鼠大脑皮层的脑组织凋亡阳性细胞数明显高于SAM－R／1；而纹状体的细胞凋亡在两品系无明显差异；针刺人中、内关及太冲可使SAM-P／10脑皮层凋亡细胞数减少，且具有明显的穴位特异性。结果提示，SAM－P／10的脑细胞的过度凋亡造成了其异常的脑萎缩；针刺对细胞凋亡的抑制作用是其治疗脑萎缩的机制之一。To study the relationship between brain atrophy and cell apoptosis and the mechanism of the therapeutic effect of acupuncture on brain atrophy, we observed cell apoptosis in the brain of Senescence Accelerated Mouse-P/10 (SAM-P/10 ) and its naturally againg control mouse SAM-R/1. The result that cell apoptosis existed in the brain of both mice, there were more apoptosis cell in the cerebral cortex of SAM- P/10 than SAM-R/1, but there were no significant difference in the striatum of both mice. Puncturing Renzhong(DU 26), Neiguan(PC 6) and Taichong(LR 3)inhibited cell apoptosis in the cerebral cortex of SAM-P/10. The result suggested that the brain atrophy may be caused by abnormal cell apoptosis in SAM-P/10, and the therapeutic effect of acupuncture on brain atrophy is associated with its inhibition effect on cell apoptosis.

关 键 词：细胞凋亡 针刺疗法 衰老 脑组织 

分 类 号：R246.6[医药卫生—针灸推拿学] R339.38[医药卫生—中医临床基础]