痰瘀通胶囊的急性毒性实验研究  

Acute Toxicity Testing of Tan-yu-tong Capsule

作　　者：叶勇[1] 杨自生[2] 朱孟祺[1] 王洁[1] 萧嘉玲[1] 

机构地区：[1]江汉大学医学院 [2]湖北中医学院

出　　处：《山西中医》2010年第1期51-52,共2页Shanxi Journal of Traditional Chinese Medicine

基　　金：湖北省科技攻关计划项目(2006AA301C04)

摘　　要：目的:通过对痰瘀通胶囊进行小鼠灌胃造成的急性毒性试验,观察其安全性,进一步为临床用药提供依据。方法:给予小鼠灌胃痰瘀通胶囊,通过预实验测定半数致死量(LD50),并据此测定最大耐受量(MTD)。结果:LD50未测出,小鼠1日最大给药量3.84g,相当于成人临床日用量的249倍。结论:痰瘀通胶囊毒性较低,在规定剂量下服用是安全可靠的。Objective： Tan -yu -tong capsule was gavaged to mice to cause acute toxicity tests, then to observe their safety, and further to provide a basis for clinical medicine. Method ： Firstly judge the possibilities of determined half lethal dose （ LD50 ） by the pre - experiment, and thus determine LD50 or the maximum tolerated dose （MTD）. Result： The largest amount of administration of mice in 1 day was 3.84g, equivalently to 249 times of clinical adult daily dosage, which showed the capsule was safe. Conclusion： Tan -yu -tong capsule has low toxicity. It is safe and reliable to take at the prescribed dose.

关 键 词：痰瘀通胶囊 急性毒性试验 半数致死量 最大耐受量 

分 类 号：R285.5[医药卫生—中药学]