急性心肌梗塞患者血肿瘤坏死因子含量的变化及其左室功能的关系  

The Circnlatory Content of Tumor Necrosis Factor in Patients with Acute Myocardial Infarction and Its Belationship with Cardiac Function

作　　者：李茵[1] 胡健[1] 李淑琴[1] 曾定尹[1] 

机构地区：[1]中国医科大学附属第一医院,沈阳110001

出　　处：《中国心血管杂志》1998年第4期258-260,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：为探讨肿瘤坏死因子(TNF)在急性心肌梗塞(AMI)发病过程中的意义,我们测定了50例AMI患者循环血中TNF含量,于发病后第2周以核素心血池显像测定其左心室功能(参数为左室总体射血分数、LVEF),并与正常人对比.结果表明:AMI组血TNF水平显著高于正常对照组(P<0.01);AMI组中左室功能低下者(LVEF<50%)血TNF水平显著高于左室功能正常者(LVEF≥50%)(P<0.01),提示TNF参与AMI的发生,并可促使AMI后心功能的恶化.In order to discuss the significance of tumor necrosis factor (TNF) in the pathogenesis of acute myocardial infarction (AMI) , we measured the circulatory content of TNF in 50 patients with AMI, we also measured the global left ventricular ejection fraction ( LVEF) with nuclear cardiac blood pool imaging at the second week after attack. The results: AMI group had a significantly higher TNF level than control group (F<0. 01) (In AMI group,patients with cardiac dysfunction (LVEF<50%) had a higher TNF level than patients with normal cardiac function (LVEF≥50%) (P<0. 01),These results indicated that TNF participated in the pathogenesis of AMI, and deteriorated the cardiac function.

关 键 词：肿瘤坏死因子 心肌梗塞 心血池显像 左室功能 

分 类 号：R542.220.2[医药卫生—心血管疾病]