延安地区中枢神经系统疾病患者弓形虫感染的抽样调查  

Survey of Toxoplasma gondii Infection Among Patients with Central Nervous System Diseases in Yan'an

作　　者：张晓文[1] 

机构地区：[1]陕西商洛学院化学与化学工程系,商洛726000

出　　处：《热带医学杂志》2009年第12期1454-1455,共2页Journal of Tropical Medicine

基　　金：商洛学院科研基金(No.08SKY029)

摘　　要：目的了解延安地区中枢神经系统疾病患者弓形虫(Toxoplasma gondii,TOX)的感染情况。方法应用酶联免疫吸附试验(Enzyme-linked immune absorbent assay,ELISA)对180例不明原因神经系统疾病患者和135例健康体检者进行抗弓形虫抗体(antitxoplasma antibody,ATAb)的检测。结果研究组ATAb的阳性率为28.89%(52/180),对照组为9.63%(13/135)。不同类型疾病患者ATAb阳性率分别为:脑型28.05%(23/82)、癫痫型44.44%(4/9)、精神病型32.14%(9/28)、神经衰弱型26.23%(16/61)。有宠物接触史者ATAb阳性率为47.62%(30/63),无接触史者ATAb阳性率为18.80%(22/117)。结论研究组ATAb阳性率明显高于对照组,两组问差异有统计学意义(P<0.01)。不同类型疾病患者ATAb阳性率差异无统计学意义(P>0.05)。有宠物接触史者ATAb阳性率明显高于无接触史者,两者间差异有统计学意义(P<0.01),说明TOX感染与接触宠物有关。Objective To evaluate the extent of Toxoplasma gondii infection among patients with central nervous system diseases in Yah＇an. Methods 180 patients with the unknown cause of nervous system diseases and 135 health subjects were studied. Anti-toxoplasma antibody（ATAb） was measured by ELISA method. Results Compared with the control subjects 9.63% （13/135）,28.89%（52/180）of patients in the study group were sero-positive for ATAb. The percentage of ATAb sero-positive patients with encephalopathy,epilepsyin,mental disorder and neurasthenia was 28.05% （23/82）, 44.44% （4/9）, 32.14% （9/28） and 26.23% （16/61）, respectively. 47.62% （30/63） of ATAb sero-positive patients had previous history of pets-feeding. 18.8% （22/117） of sero-positive patients had no previous history of pets-feeding. Conclusions The positive rate of ATAb of the studied group was significantly （P〈0.01） higher than the control group. There was no significant difference in the positive rate of ATAb in patients with various types of nervous system diseases （P〈0.05）. Development of ATAb is correlated with petfeeding in these patients.

关 键 词：中枢神经系统疾病 抗弓形虫抗体 ELISA 

分 类 号：R531.8[医药卫生—内科学]