80例继发性骨髓纤维化患者临床特点和骨髓活检分析  

The clinical features and bone marrow biopsy of 80 cases of secondary myelofibrosis

作　　者：董家蔷[1] 张剑[1] 聂泽强[1] 王京华[1] 李晓云[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院血液科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2009年第6期603-605,608,共4页Journal of Harbin Medical University

摘　　要：目的研究继发性骨髓纤维化(SMF)患者的临床特点和骨髓活检结果。方法80例SMF患者采用网状纤维染色(Gomori),并根据阳性结果判定纤维化程度。结果80例患者其主要病因为造血系统恶性疾病(87.5%),以慢性骨髓增殖性疾病最多(占32.5%)。就诊时网状纤维阳性程度以"+ +"～"+ + +"为主。患者就诊时血红蛋白、血小板与原发性骨髓纤维化存在明显差异(P<0.05)。结论对初诊的造血系统恶性疾病患者应行骨髓活检检查,并在判断治疗过程中密切监测骨髓活检,以判断患者在疾病发展过程中是否合并骨髓纤维化,判定患者病情预后情况。Objective To study the clinical features and results of bone marrow biopsy of secondary myelofibrosis（SMF）. Methods The Gomori method was used to judge if the patients had MF or were not SMF patients. Results The most important etiology of 80 SMF cases were malignant disease of hematological system（87. 5% ）,among them CMPD were most important （32. 5% ）. The level of reticulin fiber were from＂＋ ＋ ＂～＂＋ ＋ ＋ ＂. The level of HGB and PLT in SMF patients had obviously compared with those in IFM patients（P〈0.05）.Conclusion bone marrow biopsy may be used to intinal malignant disease of hematological system patients, and survey the condition of patients, judge if the patients had MF or not early,and the outcome of patients.

关 键 词：骨髓纤维化 继发性 临床特点 骨髓活检 网状纤维染色 

分 类 号：R551.3[医药卫生—血液循环系统疾病]