壳聚糖单胍盐酸盐衍生物的合成及其抗菌性能研究  

Synthesis and Antimicrobial Activity of Chitosan Guanidine Hydrochloride

作　　者：赵雪[1] 魏奕文[1] 展义臻 

机构地区：[1]东华大学化学化工与生物工程学院,上海201620 [2]浙江三元控股有限公司,浙江杭州311221

出　　处：《染整技术》2010年第1期37-40,共4页Textile Dyeing and Finishing Journal

摘　　要：以双氧水氧化二氧化硫脲制备三氧化硫脲,用壳聚糖和三氧化硫脲合成了一种壳聚糖胍盐酸盐衍生物,应用红外光谱和X射线衍射确认了衍生物的结构,对合成的壳聚糖胍盐酸盐衍生物进行抗菌性能测试,通过元素分析研究了不同胍取代度下壳聚糖胍盐酸盐衍生物对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌和绿脓杆菌的最低抑菌浓度,抗菌活性的研究结果表明所合成的壳聚糖胍盐酸盐聚合物具有较强的而且广谱的抗菌性能。Thiourea trioxide was synthesized by oxidation from thiourea dioxide with H O Chitosan guanidinehydrochloride derivative had been synthesized by the guanidineylation reaction of chitosan with thiourea trioxide.The structures of chitosan guanidine hydrochloride were characterized by FT-IR and XRD. The antimicrobialactivities of the chitosan guanidine hydrochloride were measured by means of the minimal inhibition concentration(MIC). The substitution degrees of guanidinylated chitosan were confirmed by elemental analysis. In vitroantimicrobial activity of guanidinylated chitosans with different substitution degrees were evaluated againststaphylococcus aureus, bacillus subtilis, escherichia coli and pseudomonas aeruginosa. The results showed thatchitosan guanidine hydrochloride derivative had wide spectrum of bacteriostasis.

关 键 词：壳聚糖胍盐酸盐 三氧化硫脲 合成 抗菌 

分 类 号：TS195.58[轻工技术与工程—纺织化学与染整工程]