之江菌素的毒性实验  

Toxicity evaluation of zhijangmycin

作　　者：施跃峰[1] 黄文彩[1] 夏湛恩[1] 桑金隆[1] 

机构地区：[1]浙江省农业科学院微生物研究所

出　　处：《中国抗生素杂志》1998年第5期383-385,共3页Chinese Journal of Antibiotics

基　　金：国家"八五"重点攻关项目

摘　　要：之江菌素对ＩＣＲ小鼠灌胃，ＬＤ５０为１１５３．８ｍｇ／ｋｇ，属低毒物质。致畸致突变试验阴性。亚慢毒性试验表明，大鼠饲喂含之江菌素４００ｐｐｍ的饲料连续２８ｄ，对生长发育、饲料利用率、血液及生化指标。The LD 50 value of zhijiangmycin was 1153.8mg/kg (po). The studies on mutage nicity and teratogenicity gave negative results. In subacute toxicity studies, rats were given food containing 200, 400, 800 ppm zhijiangmycin for 28 days. The animal praxis, body weight, hemato logical parameters as well as pathological observations of the dosage groups of 200 and 400ppm were not significantly affected.

关 键 词：之江菌素 急性毒性 亚慢毒性 诱变性 致畸性 

分 类 号：R978.1[医药卫生—药品] R965.3[医药卫生—药学]