双氯芬酸钠缓释胶囊的制备及药代动力学  

Studies on the Preparation and Pharmacokinetics of Diclofenac Sodium Sustained Release Capsules

作　　者：刘晓放 谭晓梅 张均寿[2] 孙国庆[2] 

机构地区：[1]黑龙江省医药工业研究所 [2]中国药科大学药剂学研究室

出　　处：《沈阳药科大学学报》1998年第4期242-245,共4页Journal of Shenyang Pharmaceutical University

摘　　要：研制了双氯芬酸钠缓释胶囊．结果表明：本品的体外溶出符合一级动力学方程（相关系数ｒ＞０９８），体内血药浓度经时曲线平缓持久，达到良好的缓释效果；生物利用度为９１３％；多剂量口服３天后血药浓度达到稳态；体内吸收分数与体外累积释放分数具有良好的相关性，ｒ＝０９７５（Ｐ＜００１）．An oral sustained release capsules of diclofenac sodium were developed.The in vitro release characteristics of the sustained release capsules were shown primarily to be of the first order of kinetics( r >0 98).The plasma concentration time curve of the sustained release capsules exhibited typical sustained release characteristics.the relative bioavailability in the human was about 91 30%.The steady state condition of plasma concentration was shown after they were administered orally into healthy volunteers by multiple dose for 3 days.Then a significant correlation was found between in vitro cumulative dissolution rate and in vivo absorption rate r=0 975(P <0 01).

关 键 词：双氯芬酸钠 缓释胶囊 生物利用度 

分 类 号：R971.1[医药卫生—药品] R969.1[医药卫生—药学]