知母盐制前后的药效学比较研究  

Comparative Research on Pharmacodynamics of Anemarrhena asphodeloides Bge.before and after Processing

作　　者：高慧[1] 陈缤[2] 贾天柱[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]辽宁中医药大学图书馆,辽宁沈阳110032

出　　处：《时珍国医国药》2010年第1期41-42,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家"十一五"科技支撑计划项目(No.2006BAI09B06-09)

摘　　要：目的对知母盐制前后清热、降血糖作用进行比较研究。方法采用酵母菌致大鼠高热法比较知母清热作用;采用四氧嘧啶致大鼠高血糖法比较知母降血糖作用。结果知母有明显的清热作用,盐制品与生品未见显著性差异,且低剂量组清热作用优于高剂量组;知母有明显的降血糖作用,盐制品作用明显优于生品,且随剂量增加作用增强。结论知母具有清热、降血糖作用,盐制后降糖作用有所增强。Objective To research the changes of pharmacodynamics in Anemarrhena asphodeloides Bge. before and after processing, for clarifying the principle of Anemarrhena asphodeloides Bge. processed with salt water. Methods Yeast and Alloxan were used to make model. The pharmacological effects of clearing heat and the decreasing blood glucose of Anemarrhena asphodeloides Bge. were compared before and after processing. Results Either the one processed or unprocessed could clear heat, and no significance was found between them. Anemarrhena asphodeloides Bge. could obviously decrease the blood glucose of rats. The one processed was better. Conclusion Anemarrhena asphodeloides Bge. can clear heat and decrease the blood glucose, and the later role wall increase after processing.

关 键 词：知母 盐制 清热 血糖 

分 类 号：R283.1[医药卫生—中药学]