野葡萄根、猕猴桃根对高脂血症大鼠血脂等影响的实验研究  

Experimental Study on the Effect of Wild Grape Root、Kiwi Root on Nitric Oxide and Endothelin in Hyperlipidemia Rats

作　　者：吴大梅[1] 万安霞[1] 杨长福[1] 张小容[1] 樊同涛[1] 徐中贵[1] 俞昌琪[1] 

机构地区：[1]贵阳中医学院,贵州贵阳550002

出　　处：《时珍国医国药》2010年第1期83-84,共2页Lishizhen Medicine and Materia Medica Research

基　　金：贵州省中医药管理局资助项目

摘　　要：目的观察高脂血症大鼠应用野葡萄根、猕猴桃根治疗后血清中血脂的变化及一氧化氮(NO)和内皮素(ET)的水平,以探讨野葡萄根、猕猴桃根治疗高脂血症的机理。方法将55只雄性W istar大鼠随机分为正常对照组,高脂模型组,野葡萄根、猕猴桃根组[8 g/(kg.d)]、复方葡猕汤组[11 g/(kg.d)]和辛伐他汀组[0.1 mg/(kg.d)],每组11只,观察6周。实验中监测各组大鼠血脂及血清中NO和ET的含量。结果野葡萄根、猕猴桃根治疗组的血脂水平较高脂模型组明显降低(P<0.05);血清中NO明显升高,而ET含量明显降低(P<0.05,P<0.01)。结论野葡萄根、猕猴桃根能明显降低血脂,提高血清中的NO水平并降低ET的水平。NO和ET的变化可能是其保护高脂血症大鼠血管内皮功能的重要机制之一,证实野葡萄根、猕猴桃根在治疗高脂血症及高血压病过程中起到一定的作用。Objective To evaluate the changes of serum lipids, nitric oxide （NO） and endothelin （ET） after treatment with wild grape root and Kiwi root in rats fed with hypercholesterol emulsion. Methods 55 male Wistar rats were randomly divided into control group （ n ： 11 , normal diet） , hyperlipidemia group （ n = 11 , high - cholesterol emulsion ） and Chinese medicine group （ every group n = 11, high - cholesterol emulsion plus corresponding Chinese medicine ： （8g/kg/d , 11 g/kg/d, ）. Western medicine group（ n = 8 , high - cholesterol emulsion plus simvastatin）. During 6 weeks of the experiment , serum lipids were compared among the 5 groups. , the levels of NO and ET in serum were also measured. Results After 6 weeks of treatment with Ye Putao root and Kiwi root , the levels of serum lipids were all decreased as compared with hyperlipidemia group （ all P 〈 0.05 ） ; the NO level in serum was increased significantly , while the ET level was markedly decreased as compared with hyperlipidemia group （P 〈 0. 05,0.01） . Conclusion Wild grape root,Kiwi root could effectively decrease the level of serum lipids, increase NO and decrease ET. The changes of NO and ET may play a role in the progress of hyperlipidemia. It confirmed that wild grape root and Kiwi root have certain effect on the hyperlipidemia and hypertension.

关 键 词：野葡萄根 猕猴桃根 高脂血症 一氧化氮 内皮素 

分 类 号：R285.5[医药卫生—中药学]