类风湿关节炎患者抗环瓜氨酸肽抗体血清水平与骨关节侵蚀的相关性研究  

The relationship between the level of anti-cyclic citrullinated peptide antibody and articular erosion in patients with rheumatoid arthritis

作　　者：刘志辉[1] 朱海龙[1] 葛秀君[2] 

机构地区：[1]广州中医药大学第一附属医院,510405 [2]广东药学院临床医学院

出　　处：《实用医技杂志》2010年第1期17-18,共2页Journal of Practical Medical Techniques

摘　　要：目的研究类风湿关节炎(RA)患者血清抗环瓜氨酸肽(CCP)抗体水平与骨关节侵蚀的相关性。方法检测75例RA患者与25例非RA患者血清中抗CCP抗体与IgM类风湿因子(RF)水平,并用放射学方法检测其关节侵蚀情况,分析结果的相关性。结果抗CCP抗体诊断RA的敏感性为64.0%,特异性为92.0%,比数积为20.4。骨关节侵蚀诊断RA的敏感性为54.7%,特异性为76.0%,比数积为3.8。RF诊断RA的敏感性为61.3%,特异性为76.0%,比数积为5.0。抗CCP抗体与RF和骨关节侵蚀有良好的相关性。结论抗CCP抗体是RA诊断的良好指标,对患者骨关节侵蚀的预测可能有重要意义。Objective To explore the relationship between anti-cyclic citrullinated peptide antibody （anti-CCP） and articular erosion in patients with rheumatoid arthritis （RA）. Methods The rate-nephelometry was used to detect rheumatoid factor, ELISA was used to measure the level of anti-CCP antibody, and X-ray photograph was used to check articular erosion. Results The diagnostic sensitivities of anti-CCP antibody, articular erosion and rheumatoid factor were 64.0%, 54.7% and 61.3% respectively, the diagnostic specificities of anti-CCP antibody, articular erosion and rheumatoid factor were 92.0%, 76.0% and 76.0% respectively, and odd product were 20.4, 3.8, 5.0 respectively. There was strong relativities between anti-CCP antibody in RA and articular erosion. Conclusions Anti-CCP antibody was a satisfactory marker for RA, and it may have an important role to predict the articular erosion in RA.

关 键 词：关节炎 类风湿 抗环瓜氨酸肽抗体 骨关节侵蚀 相关性 

分 类 号：R593.22[医药卫生—内科学] R734.2[医药卫生—临床医学]