热休克蛋白与围绝经期综合征防治相关性研究  

Correlative study on prevetion and treatment of perimenopausal syndrome and heat shock protein

作　　者：宋晓琳[1] 李晓泓[1] 徐莉莉[1] 王洪彬[1] 

机构地区：[1]北京中医药大学针灸学院,北京100029

出　　处：《中华中医药杂志》2010年第1期27-30,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金课题(No.90209026);北京市自然科学基金课题(No.7052037)~~

摘　　要：围绝经期妇女机体内环境急剧变化,多系统出现动荡与紊乱,机体处于一种生理性应激状态,但机体具有自调能力,这种能力可以帮助机体去调整与维持机体的自稳状态。倘若这种能力较弱或机体内环境变化得过于剧烈,使机体难以达到新的平衡,便会使围绝经期的生理性应激转变成的病理性应激,导致围绝经期综合征及围绝经期的易生疾病。热休克蛋白是细胞在应激反应中诱生的具有广泛性与非特异性的细胞保护蛋白,作为"分子伴侣"参与机体诸多生理病理过程。由于围绝经期应激反应中诱生的热休克蛋白与围绝经期时机体诸多环节如免疫、抗氧化、雌激素受体、胰岛素受体功能等密切相关,因此探讨热休克蛋白在围绝经期机体中的作用,对于防治围绝经期综合征具有重要意义。The period of perimenopausal causes an sudden change of internal environment and disorder of many systems. But the body has a self-adjusting ability, which can help the body to adjust and maintain the body＇s state of homeostasis. If this ability too weak or environmental changes in the body is too severe, so that the organism is difficult to reach a new equilibrium, the physiological stress in this time will turn into pathological stress, leading to menopause and menopause syndrome prone to the disease. Heat shock protein in the cell is the stress induced in the broad and non-specific proteins to protect the cells,as a ＇chaperone＇ involved in a number of physiological and pathological process of the body. As a result of heat shock protein is induced by stress response in peirmenopausal period and it has an intinate relationship with many links during peirmenopausal period such as neutroendocrine, immunity, antioxidation, estrogen receptor, and insulin receptor, so discussing the function of HSP will benefit the prevention of peirmenopausal syndrome.

关 键 词：热休克蛋白 围绝经期综合征 机制 

分 类 号：R711.75[医药卫生—妇产科学] R730.51[医药卫生—临床医学]