硝酸铈对小鼠非特异性免疫功能的影响研究  

Research on the Influence of Cerium Nitrate on the Non-specific Immune Function of Mice

作　　者：张铁[1] 王春光[1] 吕建存[1] 倪耀娣[1] 

机构地区：[1]河北农业大学中兽医学院,河北定州073000

出　　处：《安徽农业科学》2010年第3期1252-1253,1255,共3页Journal of Anhui Agricultural Sciences

摘　　要：[目的]探讨稀土元素对动物非特异性免疫功能的影响机制及其有效剂量。[方法]将试验小鼠随机平均分为4组,分别饲喂蒸馏水和低(2 mg/kg)、中(20 mg/kg)、高(200 mg/kg)剂量的硝酸铈溶液,50 d后测定和比较其免疫指标。[结果]对照组和低、中、高剂量组小鼠的外周血白细胞总数分别为(5.60±1.13)×109、(7.20±1.36)×109、(9.42±2.48)×109和(8.62±2.72)×109/L,表明硝酸铈可提高小鼠的外周血白细胞总数。4组小鼠的校正廓清指数分别为6.167 4±0.256 8、5.557 3±0.184 3、10.210 6±2.084 6和9.237 3±1.918 7,表明硝酸铈可提高小鼠的碳粒廓清指数。4组小鼠的脾指数为3.074 3±0.319 2、4.275 4±1.400 2、4.907 8±1.342 3和3.655 9±1.150 8,胸腺指数分别为2.217 8±0.815 6、2.341 4±1.026 7、3.695 3±0.582 1和2.868 3±0.707 3,表明硝酸铈可提高小鼠的脾指数和胸腺指数。[结论]口服硝酸铈可显著提高小鼠的非特异性免疫力,以中等剂量的效果最为显著。[ Objective ] The research aimed to discuss the influencing mechanism of a rare-earth element on the non-specific immune function of animals and its effective dose. [ Method ] The tested mice were divided into 4 groups randomly and averagely, they were fed with distilled water and low-（2 mg/kg）, middle-（20 mg/kg） and high-dose（200 mg/kg） cerium nitrate solutions resp. After 50 d, their immune indices were determined and compared. [ Result] The periphera! WBC counts of mice in control group and low-, middle- and high-dose groups were （5.60 ±1.13） ×10^9, （7.20 ±1.36） ×10^9, （9.42 ± 2.48） ×10^9 and （8.62 ±2.72） ×10^9/L resp. , showing that the cerium nitrate could enhance the peripheral WBC count of mice. The corrected clearance indices of mice in those 4 groups were 6. 167 4 ±0. 256 8, 5. 557 3± 0. 184 3, 10.210 6±2.084 6 and 9. 237 3± 1. 918 7 resp. , showing that the cerium nitrate could enhance the carbon clearance index of mice. The spleen indices of mice in those 4 groups were 3. 074 3 ± 0.319 2, 4. 275 ± 1. 400 2, 4.907 8 ± 1. 342 3 and 3. 655 9 ± 1. 150 8 resp. and their thymus indices were 2. 217 8 ± 0. 815 6, 2. 341 4± 1. 026 7, 3. 695 3 ±0. 582 1 and 2. 868 3 ±0. 707 3 resp. , showing that the cerium nitrate could enhance the spleen index and thymus index of mice. [ Conclusion] The oral cerium nitrate could enhance the non-specific immunity of mice significantly and the effect of middle-dose was most significant.

关 键 词：硝酸铈 小鼠 外周血白细胞总数 碳粒廓清率 脾指数 胸腺指数 

分 类 号：S865.13[农业科学—野生动物驯养]