二异丙基磷酸酯类化合物的合成及杀螺活性  

Synthesis and Molluscicidal Activity of Diisopropyl Phosphates

作　　者：赵青霞[1] 高琼[1] 严相平[1,2] 戴建荣[3] 刘宇[2] 王浦海[2] 

机构地区：[1]南京工业大学药学院,南京210009 [2]南京工业大学江苏省药物研究所,南京210009 [3]江苏省血吸虫病防治研究所,江苏无锡214064

出　　处：《农药学学报》2009年第4期499-502,共4页Chinese Journal of Pesticide Science

基　　金：江苏省社会发展科技计划项目(BS2007060)

摘　　要：为了寻找新的高效、低毒灭螺药,以取代苯乙腈为原料,经成肟、磷酰化等反应,制得9个新的二异丙基磷酸酯类化合物(3a^3 i),其结构经元素分析、IR、1H NMR和M S确证。初步杀螺活性筛选结果表明,化合物3b和3h具有显著的杀螺活性,其半致死浓度LC50值分别为0.50mg/L和0.35mg/L。In order to search for novel more effective and less toxic molluscicides, nine new diisopropyl phosphates （3a-3i） were synthesized from substituted phenylacetonitriles by oximation and phosphorylation. The new compounds were confirmed by elemental analyses, IR, 1HNMR and MS. Preliminary biological screening showed that compounds 3b and 3h appeared to have significant molluscicidal activity against Oncomelanis hwpensis snails. The LC50 value of the compounds 3b and 3h against snails were 0.50 mg/L and 0.35 mg/L, respectively.

关 键 词：二异丙基磷酸酯 合成 钉螺 杀螺活性 

分 类 号：O657.63[理学—分析化学]