正交设计优化棉酚结晶法拆分衍生化工艺  

Study on Technology of Resolution of the Optical Active Derivatives of Gossypol by Crystallization Method by Orthogonal Designing Method

作　　者：代友彪[1] 唐辉[1] 张欢[1] 关丽[1] 杨四涛[1] 

机构地区：[1]石河子大学药学院/新疆特种植物药资源教育部重点实验室,石河子832002

出　　处：《石河子大学学报（自然科学版）》2009年第6期747-749,共3页Journal of Shihezi University(Natural Science)

基　　金：教育部重点科技研究项目(205815);新疆兵团博士资金项目(2009JC14)

摘　　要：为优化棉酚结晶法拆分关键过程——衍生化反应的工艺条件。采用正交设计法,重点考察反应温度、衍生化料液体积、反应时间3个因素对结晶产物收率的影响。衍生化料液体积对反应结晶产物收率的影响最为显著,其次是反应温度和时间。因此可知,优化的棉酚结晶法拆分衍生化工艺稳定、合理可行。To study and optimize on the Key processes of the resolution of the optical active derivatives of gsssypol by crystallization method Conditions of Derivatized. Using the orthogonal design to study the influence of temperature, reaction time and solvent on the yield of recrystallization is investigated. The effects of ratio of reaction solvent on the yield of the product was most remarkable, and next came reaction temperature and time. The optimal process is stable and feasible.

关 键 词：棉酚 衍生化反应 正交设计 

分 类 号：R284.1[医药卫生—中药学]