血清TNF-α、IL-6检测对慢性充血性心衰的临床价值  

Clinical Significance of Measurement of TNF-α、IL-6 in Patients with Chronic Congestive Heart Failure

作　　者：陈阵[1] 杨春[1] 李民[2] 

机构地区：[1]大连医科大学附属第一医院检验科,辽宁大连116011 [2]解放军第210医院检验科,辽宁大连116021

出　　处：《临床军医杂志》2009年第6期1035-1036,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨慢性充血性心力衰竭(chronic congestive heart failure,CHF)患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)检测的价值。方法用放射免疫方法测定176例CHF患者和30例健康人血清中TNF-α、IL-6水平。比较分析CHF患者与正常人以及不同心功能程度的CHF患者之间TNF-α、IL-6水平的变化。结果CHF患者血清中TNF-α、IL-6水平明显高于正常对照组(P<0.05),且均随着心衰程度的加重而增高,呈高度正相关。不同程度心衰患者之间TNF-α、IL-6水平均有明显差异(P<0.01)。结论CHF患者存在免疫激活和心肌炎症反应,心衰程度越重,炎症反应也越明显。放射免疫方法测定TNF-α、IL-6对CHF病程及治疗疗效预后判断具有重要的价值。Objective To study the clinical significance of the detection of TNF-αand IL-6 in serum by RIA in Patients with Chronic Congestive Heart Failure.Methods The serum levels of TNF-αand IL-6 were determined by RIA in both 176 CHF cases with New York Heart Association Classification（NYHA） of grade Ⅱ to Ⅳ and 30 healthy physical examines as normal cases of control.Results There were insignificant differences in the serum levels of TNF-αand IL-6 between CHF patients with cardiac function of grade Ⅱ and control group（P〉0.05）.The serum levels of TNF-αand IL-6 were significantly higher in CHF patients above grade Ⅲ than that of control group（P〈0.05）,and there were significant differences between the CHF patients with cardiac function of grade Ⅱ and Ⅲ,grade Ⅱ and Ⅳ,grade Ⅲ and Ⅳ（P〈0.01）.The serum levels of TNF-αand IL-6 were increased with the severity of CHF.Serum IL-6 level was positively correlated with that of TNF-α（r=0.42,P〈0.05）.Conclusion Immunological activation and myocardial inflammation exist in CHF patients.The increasing levels of TNF-αand IL-6 can promote the onset and development of CHF.The detection of TNF-αand IL-6 in serum by RIA should be of great significance to the pathogenesis of CHF.

关 键 词：慢性充血性心力衰竭 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R541.61[医药卫生—心血管疾病]