Electrochemical behaviors of lomefloxacin at a single-wall carbon nanotube-modified electrode and its interaction with bovine serum albumin  

作　　者：XU Maotian KONG Fenying ZHANG Yintang 

机构地区：[1]Department of Chemistry, Shangqiu Teachers College,Shangqiu 476000, China

出　　处：《商丘师范学院学报》2009年第12期46-53,共8页Journal of Shangqiu Normal University

基　　金：National Natural Science Foundation of China (No. 20775047);the Natural Science Foundation of Henan Province (No. 0511022300)

摘　　要：The electrochemical behaviors of lomefloxacin at a single-wall carbon nanotube-modified glassy carbon electrode have been investigated by cyclic voltammetry.In a Britton-Robinson buffer (pH 4.5),lomefloxacin yields a sensitive and well-defined oxidation peak at ca.1.24 V (vs.SCE) on the modified electrode.Compared with the bare glassy carbon electrode,the oxidation peak current of lomefloxacin significantly increases and the oxidation peak potential positively shifts.Under the optimal conditions,the interaction of lomefloxacin with bovine serum albumin is also investigated.The results indicate that an electrochemically inactive supramolecular complex is formed and the formation of complex between lomefloxacin and bovine serum albumin is an intercalation mechanism.The proposed methods offer a reference for the studies on the biological effects and action mechanism of lomefloxacin with albumins in vivo.The electrochemical behaviors of lomefloxacin at a single -wall carbon nanotube -modified glassy carbon electrode have been investigated by cyclic voltammetry. In a Britton - Robinson buffer （ pH 4. 5 ）, lomefloxacin yields a sensitive and well - defined oxidation peak at ca. 1.24 V （ vs. SCE） on the modified electrode. Compared with the bare glassy carbon electrode, the oxidation peak current of lomefloxacin significantly increases and the oxidation peak potential positively shifts. Under the optimal conditions, the interaction of lomefloxacin with bovine serum albumin is also investigated. The results indicate that an electrochemically inactive supramolecular complex is formed and the formation of complex between lomefloxacin and bovine serum albumin is an intercalation mechanism. The proposed methods offer a reference for the studies on the biological effects and action mechanism of lomefloxacin with albumins in vivo.

关 键 词：电化学分析法 电气化学 SCE LMF 

分 类 号：O657.1[理学—分析化学]