消除大鼠深部脑刺激伪迹的实验研究  

Research of Deep Brain Stimulation Artifact Removal in Rats

作　　者：高东明[1] 刘春娜[2] 亢宁[1] 林宇涵[1] 张晓黎[1] 

机构地区：[1]辽宁医学院生理学教研室 [2]辽宁医学院药理学教研室,辽宁锦州121001

出　　处：《辽宁医学院学报》2009年第6期497-498,575,576,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：辽宁省教育厅基金项目资助;编号:2008423

摘　　要：目的消除刺激伪迹,以揭示DBS的作用机制。方法Spike 2系统特有的生物信号处理功能,综合使用数字滤波、双窗口电位与信号波形鉴别方法消除刺激伪迹。结果经刺激伪迹消除处理可以清楚显示脑内高频刺激期内神经元的放电活动的变化。结论我们的方法可有效地清除刺激伪迹。Objective The research aims to remove the stimulus artifact,and to explore the mechanism of deep brain stimulation. Methods Through using the functions of digital filter,spike waveforrn detection and potential filter in two windows performed by the Spike 2 system,the stimulus artifact was eliminated.Results The change of neural discharge activities during deep brain stimulation could be revealed clearly.Conclusions The method can be effectively used in the stimulus artifact removal.

关 键 词：深部脑刺激 刺激伪迹 大鼠 

分 类 号：Q421[生物学—神经生物学]