老年高血压患者颈动脉粥样硬化与血尿酸超敏C反应蛋白和补体的相关性研究  

Study on the relationship between the level of high sensitivity C-reactive protein,complement and serum uric acid in elderly patients with carotid atherosclerosis and hypertension

作　　者：刘爱学[1] 王蕴[1] 王小娟[1] 于常英[1] 梁晓慧[1] 

机构地区：[1]秦皇岛市第一医院,河北秦皇岛066200

出　　处：《西部医学》2010年第1期32-34,共3页Medical Journal of West China

基　　金：河北省科技厅2005年科研项目(No.052761824)

摘　　要：目的比较老年高血压患者血清超敏C-反应蛋白(hs-CRP)、血尿酸(UA)水平、补体C3与血压及颈动脉粥样硬化程度的相关性。方法将112例老年高血压患者按血压值的不同分为三组,比较各组间hs-CRP、UA与血压的相关性,对各例患者分别检测血生化指标:血清hs-CRP、UA、C3,B超观察颈动脉内膜变化,按B超结果将患者分为内膜正常组、内膜增厚组、斑块形成组和管腔狭窄组,比较各组间hs-CRP、UA、C3水平。结果高血压3级患者hs-CRP、UA显著高于高血压1级、2级患者,差异有统计学意义(P<0.05)。1-3级高血压患者3组hs-CRP、UA值各组间比较差异有统计学意义(P<0.05)。颈动脉内膜异常组hs-CRP、UA、C3值明显高于内膜正常组,比较差异有统计学意义(P<0.01)。随着颈动脉内膜中层厚度(IMT)的增厚,UA、hs-CRP的浓度亦逐渐增高,各组间比较差异均有显著性(P<0.05)。结论老年高血压患者颈动脉粥样硬化程度与血压、UA、hs-CRP和C3浓度密切相关。老年高血压病患者血压、hs-CRP、UA、浓度与IMT厚度呈正相关关系(P<0.01)。Objective To research the relationship between high sensitivity C-reactive protein（hs-CRP）, C3 and u- ric acid （UA） in elderly patients with carotid atherosclerosis and hypertension. Methods 112 people were divided into three groups according to blood pressure. The carotid with intimae tricking, plaque shaping and vascular stenosis were observed with ultrasound. The serum hs-CRP, C3 and UA were measured. Results hs-CRP and UA were different in those three grade hypertension（P〈0.05）, which were higher in grade 3 hypertension than that in grade 1 and grade 2 hypertension （P〈0.01）. Conclusions hs-CRP and UA are related to hypertension in the elderly, compare artery intimae tricing（IMT）.

关 键 词：高血压 尿酸 超敏C反应蛋白 补体C3 颈动脉 

分 类 号：R544.1[医药卫生—心血管疾病]