明胶微球控释示踪研究  

TRACE STUDY OF SLOW RELEASE ON GELATIN MICROSPHERE

作　　者：仝健[1] 李耀玲[1] 冯云[1] 李怀芬[2] 牛惠生[2] 

机构地区：[1]天津医科大学口腔医院 [2]中国医学科学院放射医学研究所

出　　处：《同位素》1998年第3期168-171,共4页Journal of Isotopes

摘　　要：采用明胶作赋形剂包埋１２５Ｉ－纤维蛋白原（１２５Ｉ－ＦＧ）制备出直径４０—８０μｍ的明胶微球控释剂型。微球直径决定药物释放的速率，纤维蛋白原包埋率达９０％。微球注入皮下通过组织对微球的分解而释放被包埋的药物，血药峰值在第６ｄ出现；药物在主要脏器内无储留，植入部位无刺激反应，植入后１５ｄ微球完全吸收。这表明明胶微球是一种理想的药物控释剂型。The microsphere of the diameter of 40-80 μm is made of 125 I fibrinogen[ 125 I FG] and gelatin. The encapsuled rate of 125 I FG is over 90%.There is a 125 I FG peak in blood after six days of subcutaneous injection and the microsphere is almost absorbed completely at the fifteenth day. There is no stimulative reaction in injection place. Gelatin microsphere is a ideal style of successful control release drug.

关 键 词：明胶微球 放射性示踪 碘125 纤维蛋白原 

分 类 号：R817[医药卫生—影像医学与核医学]