PDGF、TGF-β_1在人断层皮片供区创面愈合过程中的基因表达及意义  

PDGF,TGF-β_1 gene expressions during wound healing of the split-skin graft donor site in human

作　　者：王雪[1] 牛星焘[1] 陈东明[1] 

机构地区：[1]北京医科大学第三临床医学院成形外科,100083

出　　处：《中华整形烧伤外科杂志》1998年第5期358-360,共3页

基　　金：本课题受国家自然科学基金资助

摘　　要：目的探讨血小板源生长因子(PDGF)、转化生长因子-β_1(TGF-β_1)对伤口愈合的影响。方法用原位杂交技术观察人断层皮片供皮区创面愈合过程中内源性 PDGF、TGF-β_1的基因表达。结果发现人断层皮片供皮区创面愈合过程中内源性 PDGF、TGF-β_1的基因有明显表达。结论其表达规律性在创面愈合过程中可能起着重要的调控作用。Objective A series of studies has shown that exogenous growth factors could en- hance healing in different types of wounds.This study was to investigate endogenous changes in growth factors during the process of wound healing.Method In situ hybridization was used to examine the ex- pression of endogenous PDGF mRNA and TGF-β_1 mRNA in the process of wound healing of a split-skin graft donor site in human.Result The results demonstrated that there were obvious expressions of endogenous PDGF and TGF-β_1 during wound healing.Conclusion The regularity of its expression has close correlation with the time of wound healing,suggesting PDGF and TGF-β_1 might play key roles in wound healing.

关 键 词：创面愈合 血小板源 生长因子 转化生长因子 

分 类 号：R641.02[医药卫生—外科学]