支气管哮喘患者中医辨证分型与尿四种微量蛋白的关系  

Relationship between Syndrome Type in TCM and Four Trace Urinary Proteins in Patients with Bronchial Asthma

作　　者：陈安忠[1] 赵社正 黄少檀 程莉[1] 叶友联 

机构地区：[1]解放军第458医院,广州510602

出　　处：《中国中西医结合杂志》1998年第9期537-539,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的 :探讨哮喘患者中医不同证型与尿中 4种微量蛋白的关系。方法 :用放射免疫法测定 2 17例哮喘患者尿中 4种微量蛋白 ,并与 6 6名健康人组对比。结果 :哮喘患者尿白蛋白 (UAlb)、尿免疫球蛋白G (UIgG)、尿 β2 微球蛋白 (Uβ2 m)、尿Tamm Horsfall蛋白(UTHP)呈不同程度增高 ,并按中医肺虚型、肺脾两虚型和肺肾两虚型顺序呈渐增趋势。并证实尿 4种微量蛋白测定对肾功能受损判断较血BUN、SCr灵敏。结论 :哮喘患者中医证型有其客观的物质基础 ,即其存在不同程度的肾小球滤过Alb、IgG功能受损 ,肾小管重吸收β2Objective: To explore the possible relationship between Syndrome Type in TCM and the 4 trace urinary proteins in patients with bronchial asthma. Methods: The 4 kinds of trace urinary proteins in 217 patients with asthma were measured by radioimmunoassay, and that in 66 normal subjects were compared. Results: The results showed that there were increments of urinary albumin, urinary IgG, urinary β 2 microglobulin and urinary Tamm Horsfall protein in patients with asthma; and the gradual increase tended to be accompanied by the continuous aggravation of patient's condition on TCM Syndrome Type. Furthermore, these datas proved that the 4 trace urinary proteins might be the most sensitive indicators for detecting impaired renal functions than serum blood urea nitrogen and creatinine. Conclusions: There were the objective material foundations on TCM Syndrome Type in asthmatics, which consisted of renal glomerular dysfunctions to filter out albumin and IgG, renal tubular dysfunction to reabsorb β 2 microglobulin, and to synthesize and excrete Tamm Horsfall protein.

关 键 词：哮喘 中医证型 白蛋白 IGG Β2微球蛋白 

分 类 号：R256.120.2[医药卫生—中医内科学]