苯丙胺类中枢兴奋剂依赖者事件相关电位P_(300)波形特点及其分析研究  

ANALYSIS STUDY OF THE VARIABILITY FEATURE OF P_(300) IN PATIENTS WITH AMPHETAMINE TYPE STIMULANTS DEPENDENCE

作　　者：张尧[1] 徐再锋[1] 张昌勇[1] 田艳[1] 汤珺[1] 

机构地区：[1]华中科技大学同济医学院附属精神卫生中心武汉市精神卫生中心,武汉430022

出　　处：《中国药物依赖性杂志》2009年第6期474-477,共4页Chinese Journal of Drug Dependence

基　　金：国家自然科学基金项目(30800364)资助

摘　　要：目的:探讨苯丙胺类中枢兴奋剂(ATS)依赖者事件相关电位P300主要指标的变化特点及其与临床精神症状的相互关系。方法:对40例ATS依赖病例(研究组)和30例本院职工或家属(对照组)进行事件相关电位P300的检测,并使用症状自评量表对研究组进行评定。结果:ATS依赖者靶刺激N2潜伏期(245.74ms±s12.60ms)、P3潜伏期(318.46ms±s18.77ms)、P2-N2峰间潜伏期(69.13ms±s10.76ms)较正常对照组(238.81ms±s13.70ms,310.27ms±s11.41ms,65.23ms±s11.58ms)延长,均P<0.05,P3波幅(5.31ms±s2.39ms)低于正常对照组(9.50ms±s1.58ms),P<0.01;伴有精神病性症状的ATS依赖者P3波幅(4.64uv±s2.96uv)低于不伴有精神病性症状的依赖者波幅(5.73uv±s3.66uv),P3潜伏期(320.36ms±s19.23ms)较不伴有精神病性症状的依赖者(312.73ms±s18.19ms)延长,P<0.05;N2潜伏期与焦虑分(r=-0.366)、偏执分呈负相关(r=-0.386);P3潜伏期与精神病性症状分(r=-0.430)、躯体化分呈负相关(r=-0.397);P3波幅与精神病性症状分呈负相关(r=-0.486)。结论:ATS依赖者存在明显的认知功能损害,其中N2潜伏期、P3潜伏期及P3波幅与ATS依赖者的多种临床症状呈相关性。Objective：To explore the variability feature of P300,and the correlation between P300 and clinical manifestation in patients with amphetamine type stimulants（ATS）dependence.Methods：Forty ATS dependent patients and 30 normal controls were assessed by auditory event-related potential P300 with Galileo Sirius 32 channels digital evoked potential systems and SCL-90.Results：In comparison with normal controls（N2 238.81±s 13.70 ms,P3 310.27 ms±s 11.41 ms,P2-N2（65.23 ms±s 11.58 ms,P3 9.5 0 ms±s 1.58 ms）,ATS dependent patients had longer latency of N2（245.74 ms±s 12.60 ms）,P3（318.46 ms±s 18.77 ms）and inter-peak latency of P2-N2（69.13 ms±s 10.76 ms）,P0.05,and lower amplitude of P3（5.31 ms±s 2.39 ms）,P0.01.ATS dependent patients with psychotic symptoms had lower amplitude of P3（4.64 uv±s 2.96 uv）and longer latency of P3（320.36 ms±s 19.23 ms）than those without psychotic symptoms（5.73 uv±s 3.66 uv,312.73 ms±s 18.19 ms）,P0.05;latency of N2 was inversely correlated to anxiety（r=-0.366）and paranoia（r=-0.386）;latency of P3 was inversely correlated to psychiatric symptoms（r=-0.430）,somatization（r=-0.397）,amplitude of P3 was inversely correlated to psychiatric symptom（r=-0.486）.Conclusion：ATS dependent patients suffer from cognitive dysfunction.Latency of N2,P3 and amplitude of P3 have different correlations with many psychotic symptoms.

关 键 词：苯丙胺类相关性障碍 事件相关电位P300 行为症状 精神病性症状 

分 类 号：R595.4[医药卫生—内科学] R395.2[医药卫生—临床医学]