慢性血透患者血浆内皮素、心钠素、肾素和血管紧张素的相关研究  

Correlation Analysis on ET, ANP and PRA, ATⅡ in Chronic Hemodialysis Patients

作　　者：罗国华[1] 李光明[1] 崔杰[1] 张桂萍 丁虹 

机构地区：[1]武警上海总队医院肾内科和核医学研究所,上海201103

出　　处：《标记免疫分析与临床》1998年第3期123-125,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为探讨慢性血透（HD）对血管活性因子水平的影响，本文应用放射免疫分析法，测定了23例患者HD前后血浆内皮素（ET）、心钠素（ANP）、血浆肾素活性（PRA）、血管紧张素Ⅱ（ATⅡ）水平。另有健康对照者30人。结果表明：血透患者于HD前后ET、ANP、PRA、ATⅡ均高于对照组，其差别均有高度显著意义。患者HD前后比较，除PRA下降外，ANP、ATⅡ均上升（P＜0.01），ET亦升高，但无统计学意义（P＞0.05）。对ET与ANP、ANP与PRA行相关分析，结果无显著性。本文结果与文献报道不尽一致，说明影响血透后血管活性因子水平的机理复杂。本研究结果为血透患者应用血管紧张素转化酶抑制剂提供了依据。Radioimmunoassay was used to study the effect of dialysis on vasoactive factors in chronic hemodlalysis patients. Altogether 23 patients with chronic hemodialysis were involved in this study. ET, ANP, PRA and AT Ⅱ in plasma were tested before and after hemodialysis.Besides 30 healthy individuals served as control. Results showed that both before and after hemodialysis all of ET, ANP, PRA and AT Ⅱ were highly significantly higher in chronic hemodialysis patients than those in control. When comparison was made between before and after hemodialysis, higher ANP, AT Ⅱ (P<0. 01 ), ET(P>0.05 ) were found except PRA. Correlation analysis between ET and ANP, ANP and PRA showed that there were no significant relationships between them. This study provides a scientific basis for the use of inhibitors of angiotensin-converting enzyme in hemodialysis patients. However, the mechanism of the influence of hemodialysis on vasoactive factors remains to be further studied.

关 键 词：内皮素 心钠素 肾素 血管紧张素Ⅱ 血液透析 

分 类 号：R459.5[医药卫生—治疗学]