大鼠脊髓损伤后内皮素含量的变化  

Changes of Endothelin Content in Experimental Spinal Cord Injury in Rats

作　　者：彭新生[1] 徐钟源[2] 陈友明[1] 龙朝仪[1] 赵志毅[1] 冯家桦 

机构地区：[1]肇庆市第一人民医院骨科,肇庆526021 [2]中山医科大学放免检测中心,广州510089

出　　处：《标记免疫分析与临床》1998年第3期125-127,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：将36只大鼠随机分为6组:对照组、致伤后30min、2、4、8和24h组，以Allen氏法制备中度（50g·cm）脊髓损伤（SCI）模型，测定各组脊髓组织和血中内皮素（ET）含量。结果表明，SCI后各组伤段脊髓组织ET明显升高，2h达到高峰，与对照组比较均有显著性差异（P＜0.005），血ET变化与对照组比较无显著性差异（P＞0.05）。推测ET可能通过多种途径参与SCI后的继发损伤。Sprague Dawley rats(n = 36) were randomly divided into six groups: the control and 0.5、2、4、8 and 24 hours post injury groups. A rat SCI model was prepared by Allen's weight drop method (50g·cm)。 ET levels in spinal cord tissues and plasma of the six groups were measured. The results showed that ET contents in all the traumatized spinal cord tissues were remarkably higher than that of controls and with a peak at 2 hours post injury (P＜ 0. 005). There was no statistically significant difference between the controls and injured groups in plasma ET contents (P ＞0. 05). It is quite possible that ET plays a critical role in secondary damage following SCI.

关 键 词：脊髓损伤 内皮素 含量 

分 类 号：R651.202[医药卫生—外科学]