阿片肽链中L-苯丙氨酸的保护全合成及表征  

Total synthesis and characterization of L-phenylalanine of opioid peptides

作　　者：马燕[1] 王朝阳 

机构地区：[1]西南科技大学生命科学与工程学院,四川绵阳620010 [2]四川成都爱斯特医药技术有限公司,四川成都611130

出　　处：《精细与专用化学品》2010年第1期31-33,37,共4页Fine and Specialty Chemicals

摘　　要：L-苯丙氨酸经硝化、酯化、叔丁氧羰基(Boc)保护α-氨基、Pd/C还原对位硝基、对甲磺酰氯(MSC1)保护对位氨基、经水解反应后,在酸性条件下脱去叔丁氧羰基(Boc)基团,碱性条件下引入9-芴甲氧羰酰琥珀酰亚胺(Fmocosu),最终生成标题化合物,并且对所合成标题化合物进行了HNMR结构确证。The title compound was synthesized from L-phenylalanine via nitration, esterification, the amino of L-phenylalanine was protected using base-liable Boc group, the reduction of para nitryl was completed by Pd/ C, the para-amino group was protected using methylsufonyl chloride, after via saponification, Boc was removed in acid condition , and Fmoc osu could introduce Fmoc group in basic condition, finally the target compound was obtained, the structure was confirmed by ^1HNMR spectra.

关 键 词：L-苯丙氨酸 芴甲氧羰酰琥珀酰亚胺(Fmoc- osu) 对甲磺酰氯(MSCI) 合成 保护 

分 类 号：TQ464.7[化学工程—制药化工]