柴芍和胃颗粒对小鼠慢性浅表性胃炎模型的影响  

Effects of Chai Shao He Wei Granules on Chronic Superficial Gastritis in Mouse Model

作　　者：王欣[1,2] 李敏[1] 许文频[1] 李卫东[1] 

机构地区：[1]北京大学医学部基础医学院,北京100191 [2]山东中医药大学,山东济南250355

出　　处：《中国实验方剂学杂志》2010年第1期76-79,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：山东省高等学校优秀青年教师国内访问学者项目经费资助(20081001)

摘　　要：目的:观察柴芍和胃颗粒对甲巯咪唑致慢性浅表性胃炎小鼠的影响。方法:甲巯咪唑ig 28 d建立慢性浅表性胃炎小鼠模型,给药3周后HE染色,对小鼠胃黏膜做病理学检测;采用比色法检测胃黏膜PGE2、磷脂、氨基己糖含量;采用放免法检测血清胃泌素含量。结果:与模型组相比,柴芍和胃给药组能减轻甲巯咪唑致慢性浅表性胃炎小鼠胃黏膜的病理性损伤,增加黏膜氨基己糖含量,提高黏膜磷脂、PGE2水平,降低血清胃泌素水平,以2 g.kg-1剂量组作用更为明显。结论:柴芍和胃可以明显减轻甲巯咪唑致慢性浅表性胃炎小鼠胃黏膜的炎症和损伤,保护胃黏膜,其机制可能与增加小鼠胃黏膜氨基己糖含量,提高黏膜磷脂、PGE2的水平,降低血清胃泌素水平有关。Objective： To observe the effects of Chai Shao He Wei Granules （CSHW） on chronic superficial gastritis in mouse model induced by methimazole. Methods： Established mice model of chronic superficial gastritis by administrating methimazole for 28 days; Three weeks after drug administration histopathology of gastric mucosa was observed by HE stain. The contents of PGE2, phosphatide and aminohexose in gastric mucosa were detected by chemical colorimetry; and the content of serum gastrin was detected by radioimmunoassay. Results： Compared with model group, CSHW high dose group could reduce the pathological damage of chronic superficial gastritis in mice, increase the content of aminohexose, elevate the levels of PGE2 and phosphatide and reduce the level of gastrin in serum, respectively. Conclusions： CSHW could obviously reduce the inflammation and damage in gastric mucosa of chronic superficial gastritis induced by methimazole in mice and protect the gastric mucosa. The effect may be related to the increase of aminohexose in gastric mucosa, raise of phosphatide and PGE2, reduction of serum gastrin.

关 键 词：柴芍和胃颗粒 慢性浅表性胃炎 机制 小鼠 

分 类 号：R285.5[医药卫生—中药学]