血清白介素-10水平与2型糖尿病大血管并发症关系的研究  

Relationship between Plasma IL-10 Level and T2DM Macrovascular Complications

作　　者：王月影[1] 崔丽娟[2] 邱辉[2] 

机构地区：[1]哈尔滨医科大学附属第一医院内分泌科实验室,黑龙江省哈尔滨市150001 [2]哈尔滨医科大学附属第一医院内分泌病房

出　　处：《中国全科医学》2010年第3期235-236,共2页Chinese General Practice

摘　　要：目的探讨血清白介素-10(IL-10)水平与2型糖尿病(T2DM)大血管并发症的关系。方法选择84例T2DM患者,其中T2DM伴大血管病变者50例(大血管病变组)、T2DM无大血管病变者34例(单纯糖尿病组)。另选择50例健康体检者为正常对照组。采用ELISA试剂盒检测3组受检者血清IL-10水平。结果糖尿病大血管病变组患者血清IL-10水平显著低于正常对照组(2.7±0.9)ng/L与(4.5±1.6)ng/L,差异有统计学意义(P<0.05);单纯糖尿病组血清IL-10水平与正常对照组比较(4.0±1.4)ng/L与(4.5±1.6)ng/L,差异无统计学意义(P>0.05)。结论T2DM伴大血管病变患者血清IL-10明显降低;提示炎症参与了T2DM大血管并发症的发生、发展;IL-10可能是T2DM大血管病变的危险因素和预测因子之一。Objective To investigate the relationship between plasma IL - 10 levels and T2DM macrovascular complications. Methods A total of 84 T2DM patients were enrolled, including 50 with macrovascular lesions （ group A） and 34 without （ group B）. Anther 50 healthy subjects were chosen as control group. Serum IL - 10 levels were detected by ELISA kits in 3 groups. Results The levels of serum IL-10 were lower in group A thanin control （2. 7±0. 9 ng/L, 4. 5±1. 6 ng/L, respectively） , the difference was significant （P 〈 0 . 05 ）. There was not significant difference in IL - 10 levels between groups B and control （P 〉 0. 05 ）. Conclusion Low - IL - 10 hyperlipidemia exists in T2DM patients with macrovascular lesions, suggesting that inflammation is involved in the occurrence and development of T2DM macrovascular complications. IL - 10 may be one of the risk factors and predictors of T2DM maerovascular lesions.

关 键 词：糖尿病 2型 白介素-10 糖尿病血管病变 危险因素 

分 类 号：R587.29[医药卫生—内分泌]