小儿病毒性腹泻与心肌受损关系的研究  

Relationship between Infantile Viral Diarrhea and Myocardial Damage

作　　者：刘呈祥 唐景裕 方肇寅[3] 张晓杰 田淑娟 武振河 刘迪 赵爱杰 祖秀明 

机构地区：[1]河北省卢龙县医院儿科,066400 [2]河北省卢龙县疾病控制中心 [3]中国预防医学科学院病毒学研究所

出　　处：《中国全科医学》2010年第3期303-305,共3页Chinese General Practice

基　　金：WHO资助(V27/181/123);国家自然科学基金项目(39870032);秦皇岛市2009年第一批科学技术研究与发展计划(200901A141)

摘　　要：目的探讨轮状病毒、人类杯状病毒引起的感染性腹泻婴幼儿心肌酶及心电图的变化。方法选择卢龙县医院2006年10月—2008年3月收治的256例感染性腹泻住院患儿的粪便标本和空腹血清,检测轮状病毒、人类杯状病毒和心肌酶活性,并检查心电图。结果轮状病毒和人类杯状病毒导致的腹泻患儿谷氨酸氨基转移酶、乳酸脱氢酶、磷酸肌酸激酶和肌酸激酶同工酶的水平间差异无统计学意义(P<0.05),但均明显高于病毒检测阴性的腹泻患儿(P<0.05)。心肌酶水平增高患儿中部分心电图可有变化,极少发生心律失常和心功能不全。结论轮状病毒和人类杯状病毒感染引起的婴幼儿腹泻,可引发不同程度的心肌损害,两种病毒对心肌酶的影响无明显差异;这种病理变化是否为导致婴幼儿死亡的一种因素,需进一步探讨。Objective To explore the changes of myocardial ferment and electrocardiography （ECG） in infants with infectious diarrhea （ID） caused by rotavirus, human - calicivirus. Methods Stool specimens and fasting serum were collected from 256 ID infants admitted to our hospital from October 2006 to March 2008 to detect rotavirus, human - calieivirus and myo- cardial enzyme activity, and ECG was conducted. Results Myocardial enzymatic rotaviruses caused by rotavirus and human caliciviruses were obviously higher in ID infants than in infants with negative diarrnea （ P 〈 0. 05 ）. ECG changed in some of the infants with increased myodiacardial enzyme, rarely with arrhythmia and cardiac insufficiency. Conclusion Infantile diarrhea caused by rotavirus and human - calicivirus may lead to varying degrees of myocardial injuries. There is not significant difference in effects on myocardial enzyme between 2 viruses. Further studies are needed on whether this pathological change is a factor leading to mortality of infants and children.

关 键 词：轮状病毒 人类杯状病毒 腹泻 婴儿 心肌疾病 

分 类 号：R725.7[医药卫生—儿科]