内脏脂肪素与冠状动脉性心脏病的研究进展  

Progress in Research on Role of Visfatin in Coronary Heart Disease

作　　者：李劲松[1] 杨丽霞[1] 

机构地区：[1]成都军区昆明总医院心内科,云南昆明650032

出　　处：《心血管病学进展》2010年第1期102-105,共4页Advances in Cardiovascular Diseases

摘　　要：内脏脂肪素是新近发现的脂肪细胞分泌的特异性蛋白质,循环血液中含量较丰富。内脏脂肪素通过促炎症反应和致动脉粥样硬化形成在冠心病的发生和发展中起重要作用,在冠状动脉性心脏病的危险因素如肥胖、2型糖尿病及胰岛素抵抗中也起到重要作用。它为深入研究冠状动脉心脏病发病机制提供了一个新的思路。Visfatin is a newly detected specific protein secreted by the adipocyte. Visfatin is an active participant in the initiation and progression of coronary heart disease （ CHD ） through pro-inflammatory and pro-atherogenic effects. These effects also play a crucial role in CHD risk factors such as obesity, type 2 diabetes, and insulin resistance. The discovery of visfatin provides new possibilities in the pathogenesis of obesity and diabetes, and drug therapy for CHD.

关 键 词：内脏脂肪素 冠状动脉心脏病 胰岛素抵抗 炎症 肥胖 

分 类 号：R541.4[医药卫生—心血管疾病] Q513.5[医药卫生—内科学]