过敏性紫癜肾炎患儿免疫球蛋白E低亲合力受体的检测  

Detection of a Low-affinity receptor for immunoglobine in childre with henock-schonlein purpura nephritis

作　　者：楚海峰[1] 窦逾常[1] 郭君[1] 宋晓波[1] 张永法[2] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130033 [2]潍坊市益都中心医院

出　　处：《中国实验诊断学》2010年第1期78-79,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨过敏性紫癜肾炎患儿免疫球蛋白E(IgE)低亲合受体与发病机制的关系。方法用流式细胞仪检测过敏性紫癜肾炎患儿20例和健康同龄儿20例IgE低亲合力受体。结果过敏性紫癜肾炎患儿CD23阳性细胞(25.09%±5.92%)明显高于正常对照组(14.96%±4.54%),有显著性差异(P<0.01)。结论IgE低亲合力受体的变化可能在过敏性紫癜肾炎的发病机制中起重要作用。Objective To explore the relationship between a low-affinity receptor for immunoglobin E （IgE） and etiology of Henock-Schonlein Purpura Nephritis （HSPN） in children. Methods The ratio of CD23 positive peripheral lymphocytes in 20 cases with HSPN and 20 health children were detected by folow cytometry. Results The levels of CD23-positive peripheral lymphocytes were significonty increased in patients with HSPN （25.09% ± 5.92% ） compared with control group（ 14.96%± 4.54% ） （ P 〈 0.01 ）. Condasion It appeared that low-affinity receptor may play a significant role in the etiology of HSPN.

关 键 词：紫癜 过敏性 肾炎 免疫球蛋白E 低亲合力受体 

分 类 号：R726.9[医药卫生—儿科]