云芝糖肽配合化疗对恶性肿瘤患者的评估  

Evaluation of PSP combined with chemotherapy in the treatment of malignant tumor patients

作　　者：赖思含[1] 尹黎[1] 李雯雯[1] 徐灿[1] 鲍依稀[1] 

机构地区：[1]重庆医科大学附属第二医院检验科,重庆400010

出　　处：《中国免疫学杂志》2010年第1期51-56,65,共7页Chinese Journal of Immunology

基　　金：国家自然科学基金(30471837);重庆市科委基金(CSTC;2009BB5399);重庆市教委基金(KJ060307);校办启动基金(QD200540)资助课题

摘　　要：目的:系统评价云芝糖肽配合化疗对恶性肿瘤患者生活质量、血液系统及免疫功能的影响。方法:计算机检索MEDLINE、Pubmed等数据库。按Cochrane评价标准严格评价文献,纳入高质量研究。结果:共纳入7个研究,701例患者。Meta分析结果示:云芝糖肽具有一定改善恶性肿瘤病人化疗后生活质量的作用。云芝糖肽联合化疗药物组在改善白细胞、血红蛋白、血小板方面与单纯使用化疗药物或鲨肝醇联合化疗药物组之间无明显差异。云芝糖肽联合化疗药物组可提高CD3+、CD4+、CD8+和CD4+/CD8+比值,而NK细胞无明显差异。结论:云芝糖肽配合化疗治疗恶性肿瘤有一定的疗效。但鉴于本系统评价纳入的研究大多质量低下,有必要进行更多的质量高、设计严谨、多中心的随机对照试验。Objective： To evaluate the quality of life, peripheral blood and immune function of patients with malignant tumors treated by PSP. Methods：We searched MEDLINE, Pubmed and other databases by computer. We assessed the identified studies in order to include high quality studies. Results： A total of 7 into the study, 701 cases of patients. Meta analysis showed that polysacchariopeptide treatment for patients with certain malignant tumors after chemotherapy might improve the quality of life. Polysacchariopeptide group combined with chemotherapy drugs might improve the white blood cells, hemoglobin, platelet compared to chemotherapy drugs or batyl alcohol drugs combined with chemotherapy. Polysacchariopeptide drug combined with chemotherapy may increase the CD3 ＋ , CD4 ＋ , CD8＋ and CD4＋/CD8＋ ratio, and the NK cells was no significant difference. Conclusion： PSP combined with chemotherapy to treat malignant tumors has a certain effect. However, most of trials included in the review may be of low quality, therefore, it may be neccessity to conduct multi-center randomized-controlled trials of high quality.

关 键 词：云芝糖肽 恶性肿瘤 系统评价 随机对照试验 

分 类 号：R285.6[医药卫生—中药学] R979.5[医药卫生—中医学]