模拟生物膜上铅离子毒性机理的研究  

Research on the Toxicity of Lead Ion in Mimetic Membrane

作　　者：廖天录[1] 孙国禄[1] 董会平[1] 

机构地区：[1]甘肃工业职业技术学院化学与环境工程系,甘肃天水741025

出　　处：《广东化工》2010年第1期53-55,共3页Guangdong Chemical Industry

摘　　要：以玻碳电极支撑的磷脂双层膜(s-BLM)作为生物膜的模型,Fe(CN)63-/4-为探针分子,利用循环伏安法和交流阻抗技术研究了铅离子与s-BLM的相互作用,结果表明,铅离子与s-BLM之间可以发生比较强烈的相互作用,诱发s-BLM上形成离子通道,并且作用后的s-BLM在10 mmol/L的乙二胺四乙酸(EDTA)溶液中能够自我修复,这表明采用强的鳌合剂从机体组织中将铅夺取,撤走铅离子则通道关闭。Abstract： In the paper, supported bilayer lipid membrane （s-BLM） was served as a biomembranc model and Fe（CN）^3-/4- as the probe ion. The interaction between Pb^2＋ and s-BLM was investigated by means of cyclic voltammetry and ac impedance spectroscopy.The results showed that Pb^2＋ can decrease the order/mess of Phosphatidylcholinc molecule and induce ion channel on s-BLM. The ion channel s-BLM after interaction can be self-repaired in 10 mmolL FDTA solution, which indicated that the channel was in closed state in the absence of Pb^2＋.

关 键 词：铅离子 循环伏安 交流阻抗 离子通道 支撑磷脂双层膜 

分 类 号：TQ457[化学工程—农药化工] Q73[生物学—分子生物学]