二羟基乙二肟对生殖系统的毒性研究  

STUDY OF TOXIC EFFECTS OF DIHYDROXYGLYXIME ON REPRODUCTIVE SYSTEM

作　　者：刘卫东[1] 欧阳宁慧[1] 蒋芸[1] 彭德慧[1] 

机构地区：[1]同济医科大学工业毒理研究室,武汉市航空路13号430030

出　　处：《工业卫生与职业病》1998年第5期260-261,共2页Industrial Health and Occupational Diseases

摘　　要：报道了二羟基乙二肟（DHG）高剂量时可诱发小鼠初级精母细胞染色体畸变，小鼠精子畸形率升高，对孕鼠和胚胎有毒作用，可引起孕鼠体重减轻、流产、胚胎死亡，活胎生长发育迟缓，腭裂，胎鼠畸形，下颌缺失等，致畸指数为12；病理组织检查显示：雄鼠睾丸曲细精管生精细胞层次紊乱，生精细胞减少并可见多核巨精细胞；电镜可见，雌鼠卵巢黄体细胞浆内线粒体肿大，嵴减少，基质空泡变，出现髓鞘样结构，这些结果表明高剂量的DHG对雄性和雌性大鼠或小鼠都有生殖毒性。To investigate the toxicity of dihydroxyglyxime (DHG ) in reproductive system, male micewere injected intraperitoneally with DHG 1000, 500, 50 mg/kg/day and 1000, 500 - 100 mg/kg/dayrespectively for 5 days consecutive1y. In the former experiment,the rate of mice testicle all chromo-some aberration was 6. 5 % in 1000 mg/kg group. In the latter one, measurement of sperm count,sperm mobility,organ factor of testis and morphological changes were performed in 4 and 10 weeksafter the end of exposure. The rates of sperm abnormalities in 4 weeks were 11. 48%, 7. 36%,7. 76% (P<0. 01 ). The spermia cells of testic convoluted tubules decreased and polynuclear giantcell could be seen. The results of the teratogenicity test in rats with DHG at 417 mg/kg showedweight loss, abortion, premature death, fetal aplasia, palatine cleft and abnormal mondibular. Theteratogenicity index was 12. The electronmicroscopic examination indicated edema of mitochondriaof ovarian corpus luteum cells and the structural change of medullary sheath. These results showedthat high dose of DHG would be of reproductive toxicity in male and female mice and rats.

关 键 词：二羟基乙二肟 生殖毒性 精子畸形 致畸 

分 类 号：R992[医药卫生—毒理学] R996[医药卫生—药学]