砷对机体GSH-Px活力影响的研究  

STUDY ON THE INFLUENCE OF ARSENIC ON GSH-Px ACTIVITY

作　　者：李富君[1] 孙贵范[1] 刘淑兰[1] 吕秀强[1] 陆春伟[1] 董尚武 苗丽壮[3] 

机构地区：[1]中国医科大学公共卫生学院,沈阳市110001 [2]辽宁省食品卫生监督检验所 [3]鞍钢劳动卫生研究所

出　　处：《工业卫生与职业病》1998年第5期266-268,共3页Industrial Health and Occupational Diseases

摘　　要：为探讨砷对机体GSH－Px活力的影响，给予小鼠灌胃染毒亚砷酸钠，观察急性及亚慢性染毒后小鼠全血及组织中GSH－Px活力的变化，同时探讨了接砷工人全血中GSH－Px活力的变化。结果表明：在急性实验中，全血、肝脏及心脏中的GSH－Px活力显著下降，并呈剂量-反应关系；仅在高剂量组可见肾脏中GSH－Px活力显著降低。在亚慢性染毒时．全血、心脏中GSH－Px活力于低剂量组即开始显著下降，以后逐渐降低，并呈剂量-反应关系；肝脏GSH－Px活力从中剂量组开始逐渐降低；肾脏GSH－Px活力仅在高剂量组显著降低。接砷组工人全血GSH－Px活力显著低于对照组。提示：砷对机体GSH－Px活力主要表现为抑制作用，GSH－Px可能是反应机体砷接触后的较为敏感的指标。To investigate the influence of arsenic on glutathione peroxidase (GSH-Px) activity, the acti-vity of GSH-Px in blood and tissues of mice was detected in acute and subchronic experiment. Inthe meantime, the GSH-Px activity in blood of workers exposed to arsenic was also measured, Theresults showed that in acute experiment, GSH-Px activity in blood,liver and heart decreased signif-icantly in a dose-response manner, while the decrease of GSH-Px activity in kidney could be seenonly in the high dose group. In subchronic experiment, the activity of GSH-Px in blood and heartdecreased remarkably starting from the low dose group, and then continued to decrease graduallyshowing a dose-res ponse manner. The GSH-Px activity in liver began to decrease from mediumdose group and that in kidney began to decrease only in high dose group. The activity of bloodGSH-Px in workers exposed to arsenic was significantly lower than that in the controls. It sugges-ted that the innuence of arsenic on GsH-Px activity manifested mainly the inhibition effect. GSH-Px might be one of the sensitive index reflecting arsenic exposure.

关 键 词：砷 谷胱甘肽 过氧化物酶 职业性 

分 类 号：R992[医药卫生—毒理学] R135.1[医药卫生—药学]