前列腺素E_1对老年高血压患者血脂及血液流变学的影响  

Effect of prostaglandin E1 on the blood-lipid and the blood rheology in patients with aged hypertension

作　　者：刘式祺[1] 陈敏[1] 吴森[1] 刘国林[1] 

机构地区：[1]广西壮族自治区江滨医院

出　　处：《右江民族医学院学报》1998年第3期368-369,共2页Journal of Youjiang Medical University for Nationalities

基　　金：广西自然科学基金

摘　　要：观察ＰＧＥ１对老年高血压患者的血脂及血液流变学的影响。用ＰＧＥ１治疗６０例（男４８例，女１２例，年龄６９．５±４．８岁）。用ＰＧＥ１１００～２００μｇ加０．９％生理盐水２５０～５００ｍｌ静滴，每天１次，３０天为１疗程。结果：ＰＧＥ１治疗１疗程后，血中总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬ－ｃｈ）均有明显降低（Ｐ＜０．０１），而对高密度脂蛋白（ＨＤＬ－ｃｈ）则无影响（Ｐ＞０．０５）。血液流变学中全血低切粘度、血球压积、红细胞聚集指数差异有高度显著性（Ｐ＜０．０１），而高切粘度、血浆粘度、纤维蛋白原差异有显著性（Ｐ＜０．０５），对血沉无影响（Ｐ＞０．０５）。表明：ＰＧＥ１对老年高血压患者有降低血脂和血粘度作用。The effect of prostaglandin E1(PGE1) on the blood-lipid and the blood rheology in patients with aged hypertension were observed. 60 patients (male 48, female 12, aged 69.5±4.8) were treated with PGE1, the intravenous drip of PGE1 100～200μg plus normal saline 250～500μg, once a day, 30 days of course of treatment. Results showed that one course of treatment with PGE1 later, TC, TG, LDL-ch decreased significantly (P<0.01), but it did not affect the HDL-ch (P>0.05). The exponent difference of whole blood low shear viscosity, hematocrit, and red cell aggregation in the blood rheology were greatly significant(P<0.01), and the difference of the high shear viscosity, the plasma viscosity and the fibrinogen were significant(P<0.05), and no effect to the blood sedimentation(P>0.05). It indicated that PGE1 can decrease the blood-lipid and the blood viscosity and that it is a kind of better drug to decrease the blood-lipid and to improve the blood rheology. 

关 键 词：老年人 前列腺素E1 血脂 血液流变学 

分 类 号：R544.105[医药卫生—心血管疾病]