低剂量氯吡格雷治疗不稳定心绞痛疗效观察  

Efficacy of domestic low-dose clopidogrel for patients with unstable angina pectoris

作　　者：李宇琛[1] 陈营清[1] 

机构地区：[1]天津市海河医院内科,300350

出　　处：《中华老年医学杂志》2010年第1期33-34,共2页Chinese Journal of Geriatrics

摘　　要：目的比较低剂量与常规剂量氯吡格雷治疗不稳定型心绞痛的疗效。方法将206例不稳定型心绞痛患者随机分为低剂量氯吡格雷（50mg／d）106例（低剂量组）和常规剂量组（75mg／d）102例，治疗12个月，观察心绞痛缓解程度及主要心脏不良事件（MACE）发生情况。结果低剂量组（106例）显效、有效、无效和恶化分别为56例（52．8％）、22例（20．8％）、11例（10．4％）和17例（16．0％），低剂量组分别为52例（51．0％）、20例（19．6％）、12例（11．8％）和18例（17．7％），两组比较，差异无统计学意义（Z=0．007，P〉0．05）。低剂量组死亡3例，非致命性心肌梗死2例，常规剂量死亡4例，非致命性心肌梗死2例，二者比较差异无统计学意义（x2=0．620，P〉0．05）。结论低剂量与常规剂量氯吡格雷治疗不稳定型心绞痛患者疗效无差异，且安全性好。Objective To compare the efficacy of domestic low-dose versus conventional-dose clopidogrel for patients with unstable angina pectoris （UAP）. Methods A total of 206 UAP patients were randomly assigned to low dose clopidogrel （50 mg/day） as treatment group and conventional-dose clopidogrel （75 mg/day） as control group. Treatment continued for 12 months to observe the extent of alleviating angina and major adverse cardiac events （MACE）. Results The numbers of markedly effective, effective, ineffective and worse patients were 56 （52.8%）, 22 （20.8%）, 11 （10.4%） and 17 （16.0%） in treatment group, and those were 52 （51.0%）, 20 （19.6%）, 12（11.8%） and 18（17.7%） in control group （all P〉0. 05）. There was death in3 cases, non fatal myocardial infarction in 2 cases in treatment group, and death in 4 cases, non-fatal myocardial infarction in 2 cases in control group （X2 =0. 620, P〉0.05）. Low-dose group had a lower incidence of adverse reactions. Conclusions The efficacy of low dose clopidogrel for patients with UAP is not inferior to conventional dose, and the safety is well.

关 键 词：心绞痛 不稳定型 血小板聚集 

分 类 号：R541.4[医药卫生—心血管疾病] R973.2[医药卫生—内科学]