整联蛋白结构与信号转导机制  

Integrin Conformations and Signaling Transduction

作　　者：薛霜[1,2] 独军政[1] 赵建勇[2] 高闪电[1] 常惠芸[1] 

机构地区：[1]中国农业科学院兰州兽医研究所国家口蹄疫参考实验室家畜疫病病原生物学国家重点实验室农业部畜禽病毒学重点开放实验室,甘肃兰州730046 [2]甘肃农业大学动物医学院,甘肃兰州730070

出　　处：《动物医学进展》2010年第1期63-67,共5页Progress In Veterinary Medicine

基　　金：国家"863"项目(2006AA10A204);国家支撑计划项目(2006BAD06A10)

摘　　要：整联蛋白是一类α/β异源二聚体膜受体分子,通过细胞膜的双向信号转导作用以调节细胞分化、迁移、免疫、黏附等生物学功能。整联蛋白能通过多种途径如黏附斑激酶、胞内-外离子浓度及结构域构象变化等介导细胞信号转导。近年来,研究的焦点是整联蛋白如何通过构象的改变来调节细胞信号转导以及对配体的亲和力。论文主要从分子水平上就整联蛋白结构和介导的信号转导机理进行了综述。Integrins are α/β heterodimeric membrane receptor molecules, which regulate a wide variety of cellular biological functions such as cell differentiation,migration,immune fuction and adhesion by bidirectional transmembrane signaling. Integrins can mediate cell signaling through many processes such as focal adhesion kinase,ion concentration inside and outside cell membrane,domain conformational changes,et al. Recently,an increasing number of studies focus on how conformational changes relate to the inter-domain and intra-domain shape shifting that relguates cell signaling and affinity for ligand. In this article, the mechanisms of integrin bidirectional signaling across the plasma membrane were reviewed.

关 键 词：整联蛋白 构象 信号转导 配体 亲和力 

分 类 号：Q513.2[生物学—生物化学]