改进的2-巯基-5-甲氧基咪唑并[4,5-b]吡啶合成法  

Improved Process for Synthesizing 2-Mercapto-5-methoxyimidazo[4,5-b] pyridine

作　　者：李梦龙[1] 成健[1] 曹少庭[1] 刘祖亮[1] 

机构地区：[1]南京理工大学化工学院,南京210094

出　　处：《应用化学》2010年第1期122-124,共3页Chinese Journal of Applied Chemistry

摘　　要：以2,6-二氯吡啶为起始原料,经甲氧基化、硝化、氨基化、还原及成环5步反应得到2-巯基-5-甲氧基咪唑并[4,5-b]吡啶,总收率45.7%。重点比较了2-氯-6-甲氧基吡啶和2,6-二氯吡啶硝化反应条件及收率的差异,讨论了水合肼、NaOH的用量对目标产物收率的影响。用1HNMR、MS和IR测试技术对目标产物结构进行了表征。2-Mercapto-5-methoxyimidazo[4,5-b]pyridine was obtained with 2,6-dichloropyridine as the starting material in five steps,including methoxylation,nitration,amination,reduction and cyclization.The overall yield of 2-mercapto-5-methoxyimidazo[4,5-b]pyridine was up to 45.7%.The differences between reaction conditions and yields of nitration of 2-chloro-6-methoxypyridine and 2,6-dichloropyridine were discussed,the effects of the amounts of hydrazine hydrate and the amounts of sodium hydroxide on the yield of the target product were also discussed.The structure of the target product was identified by 1H NMR,MS and IR.

关 键 词：巯基甲氧基咪唑并[4 5-b]吡啶 氨基硝基甲氧基吡啶 硝化 还原 

分 类 号：O621.3[理学—有机化学]