比色法测定复方地塞米松霜中醋酸地塞米松的含量  

Determination of Dexamethasone Acetate in Its Cream with Colorimetry

作　　者：胡祥珍[1] 费寿耆[1] 丁立光 

机构地区：[1]江苏省常州市第一人民医院 [2]苏州医学院

出　　处：《海峡药学》1998年第2期36-37,共2页Strait Pharmaceutical Journal

摘　　要：用无水乙醇提取复方地塞米松霜中醋酸地塞米松，然后与四氮唑蓝显色，在484．5nm波长处测其吸收度，并计算含量。在16～96μg·ml-1浓度范围内回归方程为C＝0．00516A－0．01000，r＝0．9995，平均回收率为99．89％（n＝5），RSD＝1．03％。该方法具简便、快速，适用于医院制剂分析。Through extraction with ethyl alcohol the color reaction of dexamethasone acetate with triphenyltetrazolium chloride was proposed to determine dexamethasone acetate in its dexamethasone cream at 484.5nm. The average recovery was 99. 89% (n = 5 ), and the coefficient of variation (RSD ) was 1. 03%. The method was simple and fast. It is suitable for the analysis of hospital preparation.

关 键 词：醋酸地塞米松 比色法 测定 复方地塞米松霜 

分 类 号：R977.11[医药卫生—药品] R927.2[医药卫生—药学]