环孢霉素A片剂和口服液在狗体内的药代动力学及相对生物利用度研究  

Pharmacokinetics and Bioavailability of Cyclosporine A Tablet in Dog

作　　者：陈鹭颖[1] 刘锡钧[1] 王宝奎[1] 裴仁九[1] 余祥彬[1] 翁东明[1] 

机构地区：[1]南京军区福州总医院药理科

出　　处：《海峡药学》1998年第2期58-60,共3页Strait Pharmaceutical Journal

摘　　要：本文报道给狗单剂量口服环孢素A片剂及口服液后体内血药浓度的高效液相色谱测定法及狗体内药代动力学和相对生物利用度研究的结果。使用3P87程序对药-时曲线进行处理，结果表明，环孢霉素A在狗体内的代谢符合一级吸收单室模型。片剂和口服液的主要药代动力学多数分别为t1／2ka为1．89±1．29h和1．33±1．55h，t1／2Kc＝937±2．23h和12．25±7．00h，tp＝4．43±4．08h和2．97±2．19h，Cmax＝608．71±154．99ng／ml和657．97±325．02ng／ml，环孢霉素A片剂对口服液的相对生物利用度为96．29％。This paper reports a HPLC method for determining the whole blood concenriation of Cyclosporine A and the pharmacokinetic parameters and bioavailability of Cycolsporine A tablet and oral solution in dog. The 3P87 program was used to calculate the pharmacokinetic parameters. The results showed that two dosage forms were both fitted to one compartmental model. t1/2k. were 1. 89± 1. 29 h and 1. 33± 1.55 h,t1/2Kc were 9. 37±2. 23 h and 12. 25± 7.00 h,tp were 4. 43±4. 08 h and 2. 97±2. 19 h,Cmax were 608.71 ±154. 99 ng/ml and 657. 97± 325. 02 ng/ml. In comparison with the oral solution, the tablet had a relative bioavailability of 96. 29 %.

关 键 词：环孢霉素A 药代动力学 生物利用度 片剂 口服液 

分 类 号：R978.11[医药卫生—药品]