小剂量罗红霉素对舒利迭治疗稳定期重度慢性阻塞性肺疾病的影响  

The effect of small dose roxithromycin on COPD in stable phase treated with seretide

作　　者：郑小珍[1] 刘积锋[1] 钟蔚[1] 刘俐伟[1] 

机构地区：[1]钦州市第一人民医院呼吸内科,广西钦州535000

出　　处：《临床肺科杂志》2010年第2期180-182,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察小剂量罗红霉素对舒利迭治疗稳定期重度慢性阻塞性肺疾病(COPD)患者的肺功能、体重指数(BMI)、生活质量评分、呼吸困难评分、痰量、6 min步行距离及血清C反应蛋白(sCRP)的影响。方法66例重度稳定期COPD患者随机分为三组:A组(22例),予吸入舒利迭(50/250)1吸/次,每天2次;B组(22例),在与A组相同的治疗上加口服罗红霉素分散片0.15 g/次,每天1次;C组(22例),口服罗红霉素分散片0.15 g/次,每天1次。三组疗程均为3个月,所有患者在治疗前和治疗结束时均进行以下检查:FEV1%、BMI、6 min步行试验、生活质量评分、痰量、呼吸困难评分及检测sCRP。结果三组患者治疗后的FEV1(%)、BMI改善无统计学意义(P>0.05),A组6 min步行距离提高、生活质量评分、呼吸困难评分、痰量及sCRP改变无统计学意义(P>0.05);B组治疗后患者的6 min步行距离提高(P<0.05),生活质量评分和呼吸困难评分及痰量显著减少(P<0.05),且sCRP水平亦降低(P<0.05),且6 min步行距离、生活质量评分、呼吸困难评分、痰量及sCRP比A组患者改善(P<0.05);C组治疗后与治疗前及A组治疗后比较痰量减少及sCRP降低,但C组治疗后6 min步行距离、生活质量评分及呼吸困难评分与治疗前及A组治疗后比较无改善。结论小剂量罗红霉素联合舒利迭对治疗重度稳定期COPD能改善6min步行试验、生活质量评分、呼吸困难评分、痰量及降低sCRP,且与sCRP有关。Objective To investigate the effects of small dose roxithromyein combined with seretide on the FEV1%, body mass index （BMI） , score of life quality and dyspnea, the volume of sputum, walking distance in six minutes and serum C reactive protein （sCRP） in patients with severe COPD in stable phase. Methods Sixty - six patients with severe COPD in stable phase were randomly assigned to group A （ treated with inhale seretide）, group B （ treated with oral administrated roxithromycin disperse tablet and inhale seretide）and group C （treated with oral roxithromyein disperse tablet）. The patients in the group A inhaled seretide（50/250 ） two time a day and a inhalans in every time. The patient in the group B were administrated roxithromycin disperse tablet orally with 0. 15 g every day besides the basic treatment of the group A. The patients of the group C were administrated roxithromycin disperse tablet orally with 0. 15 g every day. The course of the treatment for the three groups lasted for three months. The FEVI % , body mass index （BMI） , score of life quality and dyspnea, the volume of sputum, walking distance in six minutes and sCRP of all patients were observed before and after the treatment. Results After the three months treatment,there was no significant improvement of FEV1% and BMI among the three groups（P 〉 0. 05 ）. There was no significant improvement of score of life quality and dyspnea,the volume of sputum,walking distance in six minutes and sCRP in the group A（P 〉 0.05）. The score of life quality and dyspnea,volume of sputum,walking distance in six minutes and sCRP had been significantly improved in the group B （ P 〈 0.05 ）. The volume of sputum and sCRP had been significantly reduced in the group C （P 〈 0. 05 ）, but the score of life quality and dyspnea and walking distance in six minutes in the group C were not been improved （ P 〉 0.05 ）. Conclusion The small dose roxithromycin combined with seretide （50/250）can improve the score of life qualit

关 键 词：罗红霉素 小剂量 舒利迭 慢性阻塞性肺疾病 稳定期 

分 类 号：R563.9[医药卫生—呼吸系统]