豚鼠耳蜗微动脉自律运动的连续观察及分析  

A specific property of microvasomotion in the guinea pig cochlea

作　　者：史晓瑞[1,2,3] 董明敏[1,2,3] 姜泗长[1,2,3] 董民声[1,2,3] 修瑞娟[1,2,3] 

机构地区：[1]河南医科大学第一附属医院耳鼻咽喉科 [2]解放军总医院耳鼻咽喉科 [3]中国医学科学院微循环研究所

出　　处：《中华耳鼻咽喉科杂志》1998年第5期285-287,共3页Chinese Journal of Otorhinolaryngology

摘　　要：目的探讨耳蜗微动脉自律运动的频率特性、收缩特性的特征参数。方法采用微循环数字图像检测和分析方法，根据微动脉管径动态变化的跟踪测量结果，利用快速富里叶频谱转换进行定量分析。结果正常状态下耳蜗微动脉存在运动幅度较小的自律运动，自律运动的频率为（０．０２１±０．００２）Ｈｚ，振幅为（０．３７±０．１１）μｍ，管径变化范围为（１２．２９±１．９０）μｍ～（１０．４１±３．０３）μｍ，平均管径为（１１．２０±２．７０）μｍ，收缩指数为０．４２±０．１７。静脉注入Ｌ精氨酸后，耳蜗微动脉的血管运动被激活，在给药１０ｍｉｎ时振幅达（０．８４±０．０１）μｍ，频率增加为（０．０６８±０．００２）Ｈｚ，与用药前相比有显著的统计学意义。结论正常耳蜗微动脉存在运动幅度较小的自律运动，Ｌ精氨酸能显著增加微动脉自律运动的频率及振幅，增强了耳蜗微循环的功能，使耳蜗血流量增加。Objective To investigate specific property of vasomotion in cochlear microvessels and its response to the endothelium derived relaxation factor (EDRF). Methods The dynamic changes of cochlea microvessels were observed using intravital microscopy and measured by the microcirculatory image processing system. The frequency and amplitude of vasomotion were analyzed with fast Fourier transform (FFT) according to the diameter changes. Results the vasomotion of cochlear arteriole with a small amplitude existed in normal condition. The diameter changed from (10.41±3.03)μm to (12.29±1.9)μm with a mean value of (11.2±2.7)μm. The specific property of vasomotion was characterized by a frequency (0.021±0.002)Hz and amplitude of (0.37± 0.11) μm. The contraction index was determined as 0.42±0.17. The vasomotion was significantly enhanced after the administration of EDRF. Conclusion The vasomotion existed in the cochlea and EDRF can increase the cochlear blood flow by improving the vasomotion.

关 键 词：耳蜗 微动脉 图像处理 计算机辅助 自律运动 

分 类 号：R339.16[医药卫生—人体生理学] R331.35[医药卫生—基础医学]